In the present work we examined the "in vivo" effects of collagen breakdown products derived from elastase digestion on lung collagen synthesis in rabbits. It was found that i.v. injection of collagen peptides greatly enhances the collagen synthesis rate while does not affect the synthesis of non collagenous proteins. The increase of incorporation of 3H-proline in lung collagen parallels that of prolyl hydroxylase activity. The collagen synthesis, expressed as fractional rate (% day), amounted to 15% day in treated animals, resulting in a significant increase with respect to controls (11.7% day). The observations reported provide evidence that collagen breakdown products stimulate lung collagen synthesis and may play a role in collagen homeostasis

Pacini, A., Gardi, C., Corradeschi, F., Viti, A., Belli, C., Calzoni, P., et al. (1990). In vivo stimulation of lung collagen synthesis by collagen derived peptides. RESEARCH COMMUNICATIONS IN CHEMICAL PATHOLOGY AND PHARMACOLOGY, 68(1), 89-101.

In vivo stimulation of lung collagen synthesis by collagen derived peptides

Pacini, A.;Gardi, C.;Corradeschi, F.;Viti, A.;Belli, C.;Calzoni, P.;Lungarella, G.
1990-01-01

Abstract

In the present work we examined the "in vivo" effects of collagen breakdown products derived from elastase digestion on lung collagen synthesis in rabbits. It was found that i.v. injection of collagen peptides greatly enhances the collagen synthesis rate while does not affect the synthesis of non collagenous proteins. The increase of incorporation of 3H-proline in lung collagen parallels that of prolyl hydroxylase activity. The collagen synthesis, expressed as fractional rate (% day), amounted to 15% day in treated animals, resulting in a significant increase with respect to controls (11.7% day). The observations reported provide evidence that collagen breakdown products stimulate lung collagen synthesis and may play a role in collagen homeostasis
Pacini, A., Gardi, C., Corradeschi, F., Viti, A., Belli, C., Calzoni, P., et al. (1990). In vivo stimulation of lung collagen synthesis by collagen derived peptides. RESEARCH COMMUNICATIONS IN CHEMICAL PATHOLOGY AND PHARMACOLOGY, 68(1), 89-101.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/21557
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