Effect of gamma-hydroxybutyric acid on human platelet aggregation in vitro

Endogenous formation of gamma-hydroxybutyric acid (GHB) (Fig. 1) has been described in humans [1]. It is considered to be a neurotransmitter and/or neuromodulator although its precise physiological role remains unclear [1]. This molecule is used in the treatment of alcoholism and alcohol withdrawal [2±4]. GHB, at least in central nervous system, has ethanol-like activities [5,6] and it is well-known that ethanol decreases platelet function (reviewed in Refs. [7±9]). However, there are no information regarding the GHB and its effect on platelet function. Therefore, the goal of the study was to investigate the most notable GHB effects on human platelet aggregation in vitro. Alcoholists during alcohol withdrawal have enhanced platelet aggregability [10,11] and GHB could reduce the enhanced platelet reacti