Cerebral PET with [18F]-2-fluoro-2-deoxy-D-glucose has been performed in four patients with neurofibromatosis type 1 (NF1) to assess the relation between cerebral metabolic activity, MRI, and the presence of neurological symptoms, including seizures, as well as mental and language retardation. Widespread hypometabolism occurred in three of the patients. The lesions on MRI, which were localised in the subcortical white matter and grey structures, had normal rates of glucose metabolism. This finding suggests that the abnormalities seen on MRI are not due to defective blood supply, localised oedema, or grey matter heterotopic foci as previously hypothesised. The presence of the hypometabolic areas seems to be inconsistently related to the occurrence of seizures and is not proportional to the degree of mental impairment. This study provides evidence of a widespread cerebral hypometabolism that is not related to the presence of MRI abnormalities; conversely normal metabolism was present in the areas with an abnormal MRI signal.

Balestri, P., Lucignani, G., Fois, A., Magliani, L., Calistri, L., Grana, C., et al. (1994). Cerebral glucose metabolism in neurofibromatosis type 1 assessed with (18f)-2-FLUORO-2-DEOXY-d-GLUCOSE AND pet. JOURNAL OF NEUROLOGY, NEUROSURGERY AND PSYCHIATRY, 57(12), 1479-1483 [10.1136/jnnp.57.12.1479].

Cerebral glucose metabolism in neurofibromatosis type 1 assessed with (18f)-2-FLUORO-2-DEOXY-d-GLUCOSE AND pet

BALESTRI, P.;FOIS, A.;DI BARTOLO, R.;
1994

Abstract

Cerebral PET with [18F]-2-fluoro-2-deoxy-D-glucose has been performed in four patients with neurofibromatosis type 1 (NF1) to assess the relation between cerebral metabolic activity, MRI, and the presence of neurological symptoms, including seizures, as well as mental and language retardation. Widespread hypometabolism occurred in three of the patients. The lesions on MRI, which were localised in the subcortical white matter and grey structures, had normal rates of glucose metabolism. This finding suggests that the abnormalities seen on MRI are not due to defective blood supply, localised oedema, or grey matter heterotopic foci as previously hypothesised. The presence of the hypometabolic areas seems to be inconsistently related to the occurrence of seizures and is not proportional to the degree of mental impairment. This study provides evidence of a widespread cerebral hypometabolism that is not related to the presence of MRI abnormalities; conversely normal metabolism was present in the areas with an abnormal MRI signal.
Balestri, P., Lucignani, G., Fois, A., Magliani, L., Calistri, L., Grana, C., et al. (1994). Cerebral glucose metabolism in neurofibromatosis type 1 assessed with (18f)-2-FLUORO-2-DEOXY-d-GLUCOSE AND pet. JOURNAL OF NEUROLOGY, NEUROSURGERY AND PSYCHIATRY, 57(12), 1479-1483 [10.1136/jnnp.57.12.1479].
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11365/21217
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo