The suppression of growth arrest-specific (gas) gene expression by serum appeared to be independent of protein synthesis, but expression in resting cells was sensitive to 2-aminopurine, an inhibitor of intracellular protein kinases. Although accumulation of gas gene mRNA was reduced by serum, nuclear transcription of the gas-2, -3, and -5 genes was observed in serum-stimulated cells, indicating that posttranscriptional events may regulate mRNA levels. Growth induction by serum, on the other hand, led to suppression of transcription of the gas-1 gene. Cell cycle regulation and the serum response of gas-1 were lost in ras-transformed cells.

Ciccarelli, C., Philipson, L., Sorrentino, V. (1990). Regulation of expression of growth arrest-specific genes in mouse fibroblasts. MOLECULAR AND CELLULAR BIOLOGY, 10(4), 1525-1529 [10.1128/MCB.10.4.1525].

Regulation of expression of growth arrest-specific genes in mouse fibroblasts

Sorrentino, V.
1990-01-01

Abstract

The suppression of growth arrest-specific (gas) gene expression by serum appeared to be independent of protein synthesis, but expression in resting cells was sensitive to 2-aminopurine, an inhibitor of intracellular protein kinases. Although accumulation of gas gene mRNA was reduced by serum, nuclear transcription of the gas-2, -3, and -5 genes was observed in serum-stimulated cells, indicating that posttranscriptional events may regulate mRNA levels. Growth induction by serum, on the other hand, led to suppression of transcription of the gas-1 gene. Cell cycle regulation and the serum response of gas-1 were lost in ras-transformed cells.
1990
Ciccarelli, C., Philipson, L., Sorrentino, V. (1990). Regulation of expression of growth arrest-specific genes in mouse fibroblasts. MOLECULAR AND CELLULAR BIOLOGY, 10(4), 1525-1529 [10.1128/MCB.10.4.1525].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/20872
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