The suppression of growth arrest-specific (gas) gene expression by serum appeared to be independent of protein synthesis, but expression in resting cells was sensitive to 2-aminopurine, an inhibitor of intracellular protein kinases. Although accumulation of gas gene mRNA was reduced by serum, nuclear transcription of the gas-2, -3, and -5 genes was observed in serum-stimulated cells, indicating that posttranscriptional events may regulate mRNA levels. Growth induction by serum, on the other hand, led to suppression of transcription of the gas-1 gene. Cell cycle regulation and the serum response of gas-1 were lost in ras-transformed cells.
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|Titolo:||Regulation of expression of growth arrest-specific genes in mouse fibroblasts.|
|Citazione:||C., C., L., P., & Sorrentino, V. (1990). Regulation of expression of growth arrest-specific genes in mouse fibroblasts. MOLECULAR AND CELLULAR BIOLOGY, 10, 1525-1529.|
|Appare nelle tipologie:||1.1 Articolo in rivista|
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