The proto-oncogene c-kit encodes a transmembrane protein tyrosine kinase receptor. The c-kit gene has recently been shown to be allelic with the W locus. Mutations at the white spotting locus (W) affect various aspects of hematopoiesis, melanogenesis and gametogenesis during development and in the adult animal. We have investigated the expression of the proto-oncogene c-kit in mouse testicular cell populations. The c-kit mRNA was found to be expressed at high levels in spermatogonia, and at lower levels in meiotic pachytene spermatocytes. Moreover, two novel testis-specific c-kit transcripts of 3.5 and 2.3 kb are present in postmeiotic haploid germ cells. These results suggest a role of c-kit not only during testis development in the embryo, but also throughout all stages of male germ cell development after birth.
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|Titolo:||Expression of the c-kit proto-oncogene in the murine male germ cells.|
|Citazione:||Sorrentino, V., M., G., R., G., P., B., & P., R. (1991). Expression of the c-kit proto-oncogene in the murine male germ cells. ONCOGENE, 6, 149-151.|
|Appare nelle tipologie:||1.1 Articolo in rivista|
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