The sister chromatid exchange (SCE) incidence in hemopoietic organs of mice infected with polycythemic or anemic strains of Friend leukemia virus was increased early after infection only in spleen and bone marrow cells of susceptible DBA/2 mice, but not in the same types of cells of genetically resistant BALB/c and C57BL/6 mice or in lymphoid cells of DBA/2 mice. Because a comparable increase of SCE incidence was observed in DBA/2 mice given either virus strain, the effect is seemingly due to the replication-competent leukemogenic component of the two strains of Friend leukemia virus (polycythemic or anemic, either identical of intimately cross-related) rather than to the defective spleen focus-forming virus that is not biologically active in the anemic strain used in this study. The increase of SCE was dependent upon virus dosage and viability, was short lasting, and was not detectable in mice with overt leukemia. The increased SCE values were accompanied by the detection of a small (10 to 15%) fraction of cells scoring “high” (5 to 20) for SCE. Statistical evaluation shows that this fraction contributes heavily to the significance of SCE increase. It is suggested that these cells may represent the target for the Friend murine leukemia virus component of the Friend leukemia virus complex. © 1982, American Association for Cancer Research. All rights reserved.

Palitti, F., Matarese, G.P., Diana, G., Sorrentino, V., Rossi, G.B. (1982). In vivo studies of increased incidence of sister chromatid exchanges in target cells of replication-component Friend murine leukemia virus. CANCER RESEARCH, 42(11), 4753-4757.

In vivo studies of increased incidence of sister chromatid exchanges in target cells of replication-component Friend murine leukemia virus

Sorrentino, V.;
1982-01-01

Abstract

The sister chromatid exchange (SCE) incidence in hemopoietic organs of mice infected with polycythemic or anemic strains of Friend leukemia virus was increased early after infection only in spleen and bone marrow cells of susceptible DBA/2 mice, but not in the same types of cells of genetically resistant BALB/c and C57BL/6 mice or in lymphoid cells of DBA/2 mice. Because a comparable increase of SCE incidence was observed in DBA/2 mice given either virus strain, the effect is seemingly due to the replication-competent leukemogenic component of the two strains of Friend leukemia virus (polycythemic or anemic, either identical of intimately cross-related) rather than to the defective spleen focus-forming virus that is not biologically active in the anemic strain used in this study. The increase of SCE was dependent upon virus dosage and viability, was short lasting, and was not detectable in mice with overt leukemia. The increased SCE values were accompanied by the detection of a small (10 to 15%) fraction of cells scoring “high” (5 to 20) for SCE. Statistical evaluation shows that this fraction contributes heavily to the significance of SCE increase. It is suggested that these cells may represent the target for the Friend murine leukemia virus component of the Friend leukemia virus complex. © 1982, American Association for Cancer Research. All rights reserved.
1982
Palitti, F., Matarese, G.P., Diana, G., Sorrentino, V., Rossi, G.B. (1982). In vivo studies of increased incidence of sister chromatid exchanges in target cells of replication-component Friend murine leukemia virus. CANCER RESEARCH, 42(11), 4753-4757.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/20856
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