The action of cyclic-ADP-ribose was studied on calcium release from sarcoplasmic reticulum of skeletal muscles of neonatal and adult wild-type and RyR3-deficient mice. cADPR increased calcium efflux from microsomes, enhanced caffeine-induced calcium release, and, in 20\% of the tests, triggered calcium release in single muscle fibers. These responses occurred only in the diaphragm of adult RyR3-deficient mice. cADPR action was abolished by ryanodine, ruthenium red, and 8-brome-cADPR. These results strongly favor a specific action of cADPR on RyR1. The responsiveness of RyR1 appears in adult muscles when RyR3 is lacking.
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|Titolo:||Ca2+ release induced by cyclic ADP ribose in mice lacking type 3 ryanodine receptor.|
|Citazione:||Fulceri, R., R., R., R., B., A., C., E., I., A., G., et al. (2001). Ca2+ release induced by cyclic ADP ribose in mice lacking type 3 ryanodine receptor. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 288, 697-702.|
|Appare nelle tipologie:||1.1 Articolo in rivista|
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