An 'affinity index', representing the global affinity between a ligand and a biomacromolecular receptor, is proposed. It is determined as the slope of the linear relations between ΔRSE1 and the receptor concentration and has the advantage of providing a measure of the ligand-biomacromolecule global affinity which is independent of the number of interaction sites. The method was applied to the calculation of the lamotrigine-albumin affinity index.
Rossi, C., Donati, A., Bonechi, C., Corbini, G., Rappuoli, R., Dreassi, E., et al. (1997). Nuclear relaxation studies in ligand-macromolecule affinity index determination. CHEMICAL PHYSICS LETTERS, 264(1-2), 205-209 [10.1016/S0009-2614(96)01296-1].
Nuclear relaxation studies in ligand-macromolecule affinity index determination
Rossi, Claudio;Donati, Alessandro;Bonechi, Claudia;Corbini, Gianfranco;Dreassi, Elena;Corti, Piero
1997-01-01
Abstract
An 'affinity index', representing the global affinity between a ligand and a biomacromolecular receptor, is proposed. It is determined as the slope of the linear relations between ΔRSE1 and the receptor concentration and has the advantage of providing a measure of the ligand-biomacromolecule global affinity which is independent of the number of interaction sites. The method was applied to the calculation of the lamotrigine-albumin affinity index.
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https://hdl.handle.net/11365/20376