In New Zealand rabbits subjected for a 2 month period to a 1% or 2% hypercholesterolic diet, larger intimal involvement and histologically heavier lesions were observed in the animals on a hypercholesterolic diet. The intimal involvement was larger in the aortic arch. In groups of rabbits simultaneously subjected to similar diets and to i.v. CDP-choline injections, the intimal involvement appeared reduced (p < 0.01) both in the arch and in the descending tract of the thoracic aorta.
Weber, G., Auteri, A., Bianciardi, G., Fabbrini, P., Resi, L., Salvi, M., et al. (1989). Influence of CDP-choline administration on the aortic wall lesions in dietetically hypercholesterolaemic rabbits: a morphometric evaluation. DRUGS UNDER EXPERIMENTAL AND CLINICAL RESEARCH, 15(6-7), 321-323.
Influence of CDP-choline administration on the aortic wall lesions in dietetically hypercholesterolaemic rabbits: a morphometric evaluation
BIANCIARDI, G.;
1989-01-01
Abstract
In New Zealand rabbits subjected for a 2 month period to a 1% or 2% hypercholesterolic diet, larger intimal involvement and histologically heavier lesions were observed in the animals on a hypercholesterolic diet. The intimal involvement was larger in the aortic arch. In groups of rabbits simultaneously subjected to similar diets and to i.v. CDP-choline injections, the intimal involvement appeared reduced (p < 0.01) both in the arch and in the descending tract of the thoracic aorta.
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https://hdl.handle.net/11365/19739
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