Ehlers-Danlos syndrome (EDS) leads to impaired extracellular matrix (ECM) structure. Since ECM plays a major role in blood vessel geometry, we tested the hypothesis of an abnormal geometrical complexity of the visible microvascular network in EDS. Twelve patients with EDS-II or EDS-III and a control population (n=12) were examined. The geometry characteristics for the networks on the lower vestibular oral mucosa were analyzed using high-resolution photographic images. Fractal dimension, D, at 2 scales (D 1-46 and D 1-15), blood vessel tortuosity (minimum-path fractal dimension, Dmin), and relative Lempel-Ziv complexity (L-Z) values were determined. EDS vascular networks exhibited signiﬁcantly higher D 1-46 (P\.00001) and D 1-15 (P\.00001), as well as L-Z complexity (P\.00001), together with lower Dmin values (P=.0001) than controls. These ﬁndings indicate the presence of a previously unrecognized microvascular network abnormality on the oralmucosal in EDS patients, and provide an additional phenotypical marker for the condition.
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|Titolo:||Abnormal oral vascular network complexity in Ehlers-Danlos syndrome.|
|Citazione:||DE FELICE, C., Bianciardi, G., Dileo, L., Latini, G., & Parrini, S. (2004). Abnormal oral vascular network complexity in Ehlers-Danlos syndrome. ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS, 98(4), 429-434.|
|Appare nelle tipologie:||1.1 Articolo in rivista|