A new type of copolymer composed of L-histidine (ampholyte) and n-butyl methacrylate (hydrophobic moiety) was developed for the preparation of nonbiofouling surfaces. The copolymer adsorbed onto resin surfaces and made the surface very hydrophilic. The hydrophilization effect was higher than that of bovine serum albumin (BSA). When polystyrene surfaces were coated with the copolymer, both the nonspecific adsorption of protein and the adhesion of cells were significantly reduced in comparison with BSA coatijn. The newly synthesized polymer is a new and useful candidate for the preparation of nonbiofouling surfaces. © 2007 American Chemical Society.
Wada, A., Ishii, T., Casolaro, M., Tsuzuki, S., Ito, Y. (2007). Copolymers including L-histidine and hydrophobic moiety for preparation of nonbiofouling surface. BIOMACROMOLECULES, 8(11), 3340-3344 [10.1021/bm070420h].
Copolymers including L-histidine and hydrophobic moiety for preparation of nonbiofouling surface
Casolaro, Mario;
2007-01-01
Abstract
A new type of copolymer composed of L-histidine (ampholyte) and n-butyl methacrylate (hydrophobic moiety) was developed for the preparation of nonbiofouling surfaces. The copolymer adsorbed onto resin surfaces and made the surface very hydrophilic. The hydrophilization effect was higher than that of bovine serum albumin (BSA). When polystyrene surfaces were coated with the copolymer, both the nonspecific adsorption of protein and the adhesion of cells were significantly reduced in comparison with BSA coatijn. The newly synthesized polymer is a new and useful candidate for the preparation of nonbiofouling surfaces. © 2007 American Chemical Society.
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https://hdl.handle.net/11365/19286
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