Nerve cells are very responsive to weak pulsed electromagnetic fields (EMFs). Such non-ionizing radiation, with frequencies of 0–300 Hz and 0.1–100 mT, can affect several cellular activities, with unusual dose–response characteristics. The present study examined the effect of a 2-h exposure of synaptosomes on a system generating a peak magnetic field of 2 mT. We evaluated the changes of the synaptosomal mitochondrial respiration rate and ATP production, membrane potential, intrasynaptosomal Ca2+concentration, and the release of free iron and F2-isoprostanes. O2consumption and ATP production remained unchanged in exposed synaptosomes. The intrasynaptosomal Ca2+concentration decreased slowly and no depolarization of the synaptosomal membrane was detected. Finally, the release of free iron and F2-isoprostanes by synaptosomal suspensions also remained unchanged after EMF exposure. These results indicate that the physiological behavior of cortical synaptosomes was unaffected by weak pulsed EMFs. © 2009, SAGE Publications. All rights reserved.

Aldinucci, C., Carretta, A., Maiorca, S.M., Leoncini, S., Signorini, C., Ciccoli, L., et al. (2009). Effects of 50 Hz electromagnetic fields on rat cortical synaptosomes. TOXICOLOGY AND INDUSTRIAL HEALTH, 25(5), 249-252 [10.1177/0748233709103031].

Effects of 50 Hz electromagnetic fields on rat cortical synaptosomes

ALDINUCCI, C.;CARRETTA, A.;LEONCINI, S.;SIGNORINI, C.;CICCOLI, L.;PESSINA, G.
2009-01-01

Abstract

Nerve cells are very responsive to weak pulsed electromagnetic fields (EMFs). Such non-ionizing radiation, with frequencies of 0–300 Hz and 0.1–100 mT, can affect several cellular activities, with unusual dose–response characteristics. The present study examined the effect of a 2-h exposure of synaptosomes on a system generating a peak magnetic field of 2 mT. We evaluated the changes of the synaptosomal mitochondrial respiration rate and ATP production, membrane potential, intrasynaptosomal Ca2+concentration, and the release of free iron and F2-isoprostanes. O2consumption and ATP production remained unchanged in exposed synaptosomes. The intrasynaptosomal Ca2+concentration decreased slowly and no depolarization of the synaptosomal membrane was detected. Finally, the release of free iron and F2-isoprostanes by synaptosomal suspensions also remained unchanged after EMF exposure. These results indicate that the physiological behavior of cortical synaptosomes was unaffected by weak pulsed EMFs. © 2009, SAGE Publications. All rights reserved.
Aldinucci, C., Carretta, A., Maiorca, S.M., Leoncini, S., Signorini, C., Ciccoli, L., et al. (2009). Effects of 50 Hz electromagnetic fields on rat cortical synaptosomes. TOXICOLOGY AND INDUSTRIAL HEALTH, 25(5), 249-252 [10.1177/0748233709103031].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/18987
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