Decades after smallpox was eradicated and vaccination discontinued, the level of residual immunity in today's population is largely unknown. This study describes an epidemiological assessment in Italians of antibodies against the intracellular mature virus (IMV) and extracellular envelope virus (EEV) forms of Vaccinia virus. Serum samples (n=642) were taken in 1993 and 2003 from people between 11 and 102 years old. Most citizens >27 years old were positive for antibodies to IMV and EEV. These antibodies were long-lasting and similar titres were present in citizens between 30 and 100 years old. Serum samples from 1993 and 2003 displayed very similar EEV- and IMV-specific antibody titres. By using these data and demographic considerations, it was predicted that, in 2003, 46 % of the Italian population were positive for both IMV and EEV, 42 % were negative for both and 12 % were positive for one antigen. © 2005 SGM.

Pütz, M.M., Alberini, I., Midgley, C.M., Manini, I., Montomoli, E., & Smith, G.L. (2005). Prevalence of antibodies to Vaccinia virus after smallpox vaccination in Italy. JOURNAL OF GENERAL VIROLOGY, 86(11), 2955-2960 [10.1099/vir.0.81265-0].

Prevalence of antibodies to Vaccinia virus after smallpox vaccination in Italy

ALBERINI, I.;MANINI, I.;MONTOMOLI, E.;
2005

Abstract

Decades after smallpox was eradicated and vaccination discontinued, the level of residual immunity in today's population is largely unknown. This study describes an epidemiological assessment in Italians of antibodies against the intracellular mature virus (IMV) and extracellular envelope virus (EEV) forms of Vaccinia virus. Serum samples (n=642) were taken in 1993 and 2003 from people between 11 and 102 years old. Most citizens >27 years old were positive for antibodies to IMV and EEV. These antibodies were long-lasting and similar titres were present in citizens between 30 and 100 years old. Serum samples from 1993 and 2003 displayed very similar EEV- and IMV-specific antibody titres. By using these data and demographic considerations, it was predicted that, in 2003, 46 % of the Italian population were positive for both IMV and EEV, 42 % were negative for both and 12 % were positive for one antigen. © 2005 SGM.
Pütz, M.M., Alberini, I., Midgley, C.M., Manini, I., Montomoli, E., & Smith, G.L. (2005). Prevalence of antibodies to Vaccinia virus after smallpox vaccination in Italy. JOURNAL OF GENERAL VIROLOGY, 86(11), 2955-2960 [10.1099/vir.0.81265-0].
File in questo prodotto:
File Dimensione Formato  
006-2005_JGV-Putz.pdf

non disponibili

Tipologia: Post-print
Licenza: NON PUBBLICO - Accesso privato/ristretto
Dimensione 153.53 kB
Formato Adobe PDF
153.53 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11365/18675
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo