Objective: To determine whether the opioidergic system is involved in the modulation of leptin secretion in healthy and amenorrheic subjects. Design: Prospective study. Setting: Department of Obstetrics and Gynecology, University of Modena, Modena, Italy. Patient(s): Healthy subjects (n = 8) and patients with hypothalamic amenorrhea (n = 17) or hyperandrogenism (n = 7) and low body mass index (BMI). Intervention(s): Acute infusion of naloxone (4-mg bolus) and blood sampling 15 minutes before infusion; at time of infusion: and 151 30, 45, 60, 75, 90, and 120 minutes after infusion. Main Outcome Measure(s): Plasma leptin, LH, FSH, E-2, and cortisol concentrations. Result(s): Plasma leptin concentrations were lower (P <.01) in both hypothalamic and hyperandrogenic amenorrheic subjects than in healthy controls. In all groups of subjects, no significant changes in leptin levels were observed after infusion of naloxone. A significant correlation was found between leptin concentrations and BMI when all subjects were considered together (P <.05) but was not found in the single groups. Conclusion(s): The present data do not support the hypothesis that opioidergic receptors are involved acutely in the modulation of leptin release in healthy and amenorrheic women. (Fertil Steril(R) 1998;70:924-6. (C) 1998 by American Society for Reproductive Medicine.).

Genazzani, A.D., Menozzi, R., DEL RIO, G., Luisi, S., Petraglia, F., & Genazzani, A.R. (1998). Acute infusion of naloxone, an opioid receptor antagonist, does not modify serum leptin concentrations in amenorrheic and healthy women. FERTILITY AND STERILITY, 70(5), 924-926 [10.1016/S0015-0282(98)00307-0].

Acute infusion of naloxone, an opioid receptor antagonist, does not modify serum leptin concentrations in amenorrheic and healthy women

LUISI, S.;
1998

Abstract

Objective: To determine whether the opioidergic system is involved in the modulation of leptin secretion in healthy and amenorrheic subjects. Design: Prospective study. Setting: Department of Obstetrics and Gynecology, University of Modena, Modena, Italy. Patient(s): Healthy subjects (n = 8) and patients with hypothalamic amenorrhea (n = 17) or hyperandrogenism (n = 7) and low body mass index (BMI). Intervention(s): Acute infusion of naloxone (4-mg bolus) and blood sampling 15 minutes before infusion; at time of infusion: and 151 30, 45, 60, 75, 90, and 120 minutes after infusion. Main Outcome Measure(s): Plasma leptin, LH, FSH, E-2, and cortisol concentrations. Result(s): Plasma leptin concentrations were lower (P <.01) in both hypothalamic and hyperandrogenic amenorrheic subjects than in healthy controls. In all groups of subjects, no significant changes in leptin levels were observed after infusion of naloxone. A significant correlation was found between leptin concentrations and BMI when all subjects were considered together (P <.05) but was not found in the single groups. Conclusion(s): The present data do not support the hypothesis that opioidergic receptors are involved acutely in the modulation of leptin release in healthy and amenorrheic women. (Fertil Steril(R) 1998;70:924-6. (C) 1998 by American Society for Reproductive Medicine.).
Genazzani, A.D., Menozzi, R., DEL RIO, G., Luisi, S., Petraglia, F., & Genazzani, A.R. (1998). Acute infusion of naloxone, an opioid receptor antagonist, does not modify serum leptin concentrations in amenorrheic and healthy women. FERTILITY AND STERILITY, 70(5), 924-926 [10.1016/S0015-0282(98)00307-0].
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11365/18650
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