An adsorptive stripping voltammetric method with a hanging mercury drop electrode was developed for the determination of the fluoroquinolone rufloxacin in tablets, human plasma and urine. Measurements were obtained in differential pulse mode and a multivariate strategy was used to optimize the variables involved. Besides the independent effects of the variables, a strong interaction between scan rate and pulse duration has been found. Rufloxacin was analysed at concentrations between 1.7 × 10-8 and 1.9 × 10-7 M with a detection limit of 9.2 × 10-9 M. Diluted tablet solutions and urine samples were analysed directly, while plasma samples needed an extraction procedure before voltammetric analysis. An improved HPLC procedure was used as comparative method. © 1995.
Furlanetto, S., Gratteri, P., Pinzauti, S., Leardi, R., Dreassi, E., Santoni, G. (1995). Design and variable optimization in the absorptive stripping voltammetric determination of rufloxacin in tablets, human plasma and urine. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 13(4-5), 431-438 [10.1016/0731-7085(95)01288-V].
Design and variable optimization in the absorptive stripping voltammetric determination of rufloxacin in tablets, human plasma and urine
Dreassi E.;
1995-01-01
Abstract
An adsorptive stripping voltammetric method with a hanging mercury drop electrode was developed for the determination of the fluoroquinolone rufloxacin in tablets, human plasma and urine. Measurements were obtained in differential pulse mode and a multivariate strategy was used to optimize the variables involved. Besides the independent effects of the variables, a strong interaction between scan rate and pulse duration has been found. Rufloxacin was analysed at concentrations between 1.7 × 10-8 and 1.9 × 10-7 M with a detection limit of 9.2 × 10-9 M. Diluted tablet solutions and urine samples were analysed directly, while plasma samples needed an extraction procedure before voltammetric analysis. An improved HPLC procedure was used as comparative method. © 1995.
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https://hdl.handle.net/11365/18615
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