A thin-layer chromatographic (TLC) method is described for the assay of the anti-epileptic drug, valproic acid, in plasma. The use of high-performance (HPTLC) plates gave sensitive detection limits (4.87 μg ml-1) for derivatives of valproic acid and the reproducibility on the same or different plates was good. Comparison with high-performance liquid chromatography showed a similar performance of plate and column. © 1990.
Corti, P., Cenni, A., Corbini, G., Dreassi, E., Murratzu, C., Caricchia, A.M. (1990). Thin-layer chromatography and densitometry in drug assay: comparison of methods for monitoring valproic acid in plasma. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 8(5), 431-436 [10.1016/0731-7085(90)80071-V].
Thin-layer chromatography and densitometry in drug assay: comparison of methods for monitoring valproic acid in plasma
Corti P.;Corbini G.;Dreassi E.;
1990-01-01
Abstract
A thin-layer chromatographic (TLC) method is described for the assay of the anti-epileptic drug, valproic acid, in plasma. The use of high-performance (HPTLC) plates gave sensitive detection limits (4.87 μg ml-1) for derivatives of valproic acid and the reproducibility on the same or different plates was good. Comparison with high-performance liquid chromatography showed a similar performance of plate and column. © 1990.
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https://hdl.handle.net/11365/18533
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