The synthesis of a new series of sesamol derivatives with P-adrenergic blocking activity is described. The affinity and selectivity of these compounds for beta(1)- and beta(2)-adrenoceptors were studied in comparison with those of ICI-118551 and propranolol. Some of the synthesized compounds show very good affinity for the beta(2)-receptors of rat lung membranes and two of them provide interesting selectivity.

Brizzi, V., Francioli, M., Brufani, M., Filocamo, L., Bruni, G., & Massarelli, P. (1999). Synthesis, binding affinity and selectivity of new beta1 and beta2 adrenoceptor blockers. IL FARMACO, 54(11-12), 713-720 [10.1016/S0014-827X(99)00077-4].

Synthesis, binding affinity and selectivity of new beta1 and beta2 adrenoceptor blockers

BRIZZI, VITTORIO;BRUNI, GIANCARLO;MASSARELLI, PAOLA
1999

Abstract

The synthesis of a new series of sesamol derivatives with P-adrenergic blocking activity is described. The affinity and selectivity of these compounds for beta(1)- and beta(2)-adrenoceptors were studied in comparison with those of ICI-118551 and propranolol. Some of the synthesized compounds show very good affinity for the beta(2)-receptors of rat lung membranes and two of them provide interesting selectivity.
Brizzi, V., Francioli, M., Brufani, M., Filocamo, L., Bruni, G., & Massarelli, P. (1999). Synthesis, binding affinity and selectivity of new beta1 and beta2 adrenoceptor blockers. IL FARMACO, 54(11-12), 713-720 [10.1016/S0014-827X(99)00077-4].
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11365/17804
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