The synthesis of a new series of sesamol derivatives with P-adrenergic blocking activity is described. The affinity and selectivity of these compounds for beta(1)- and beta(2)-adrenoceptors were studied in comparison with those of ICI-118551 and propranolol. Some of the synthesized compounds show very good affinity for the beta(2)-receptors of rat lung membranes and two of them provide interesting selectivity.
Brizzi, V., Francioli, M., Brufani, M., Filocamo, L., Bruni, G., Massarelli, P. (1999). Synthesis, binding affinity and selectivity of new beta1 and beta2 adrenoceptor blockers. IL FARMACO, 54(11-12), 713-720 [10.1016/S0014-827X(99)00077-4].
Synthesis, binding affinity and selectivity of new beta1 and beta2 adrenoceptor blockers
BRIZZI V.;BRUNI G.;MASSARELLI P.
1999-01-01
Abstract
The synthesis of a new series of sesamol derivatives with P-adrenergic blocking activity is described. The affinity and selectivity of these compounds for beta(1)- and beta(2)-adrenoceptors were studied in comparison with those of ICI-118551 and propranolol. Some of the synthesized compounds show very good affinity for the beta(2)-receptors of rat lung membranes and two of them provide interesting selectivity.
| File | Dimensione | Formato | |
|---|---|---|---|
|
Il Farmaco 1999, 713-720.pdf
non disponibili
Tipologia:
Post-print
Licenza:
NON PUBBLICO - Accesso privato/ristretto
Dimensione
136.96 kB
Formato
Adobe PDF
|
136.96 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
https://hdl.handle.net/11365/17804
Attenzione
Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo