(Matrix Presented) β-Lactams were prepared on solid phase starting from serine, threonine, or other β-hydroxyacids derived from naturally occurring amino acids and a resin bound hydroxylamine. The ring closure was carried out under Mitsunobu conditions. The amino group present on the β-lactam was used to assemble a short peptide. After a reductive cleavage with Sml2, β-lactam-containing peptides were obtained.
Meloni, M.M., Taddei, M. (2001). Solid-phase synthesis of beta-lactams via the Miller hydroxamate approach. ORGANIC LETTERS, 3, 337-340 [10.1021/ol006779z].
Solid-phase synthesis of beta-lactams via the Miller hydroxamate approach
Taddei, Maurizio
2001-01-01
Abstract
(Matrix Presented) β-Lactams were prepared on solid phase starting from serine, threonine, or other β-hydroxyacids derived from naturally occurring amino acids and a resin bound hydroxylamine. The ring closure was carried out under Mitsunobu conditions. The amino group present on the β-lactam was used to assemble a short peptide. After a reductive cleavage with Sml2, β-lactam-containing peptides were obtained.
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https://hdl.handle.net/11365/17731
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