The objective of this study was to further clarify the cancer risk associated with asbestos exposure in railway Carriage construction and repair. The cohort included 734 subjects employed between 1 January 1945 and 31 December 1969. Vital status was ascertained at 31 December 1997. Mortality was investigated in the time span 1970–97. Forty-two subjects (6%) were lost to follow-up and eight causes of death (4%) could not be ascertained. The overall mortality was not above the expected value. Among neoplastic diseases, excesses were observed for lung [standardized mortality ratio (SMR) = 124; 90% confidence interval (Cl) = 87–172; 26 obs), pleura (SMR = 1,327; Cl = 523–2,790; 5 obs), larynx (SMR = 240; Cl = 95–505; 5 obs), liver (SMR = 241; Cl = 126–420; 9 obs), pancreas (SMR = 224; Cl = 98–443; 6 obs) and multiple myeloma (SMR = 429; Cl = 117–1,109; 3 obs). The observed excess of lung and pleural neoplasms can be causally related to asbestos exposure in the manufacture of railway carriages. A causal role of asbestos exposure in the raised SMRs from laryngeal and pancreatic neoplasms and multiple myeloma cannot be conclusively proven.
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http://hdl.handle.net/11365/17193
Titolo: | Mortality due to asbestos-related causes among railway carriage construction and repair workers |
Autori: | |
Anno: | 1999 |
Rivista: | |
Abstract: | The objective of this study was to further clarify the cancer risk associated with asbestos exposure in railway Carriage construction and repair. The cohort included 734 subjects employed between 1 January 1945 and 31 December 1969. Vital status was ascertained at 31 December 1997. Mortality was investigated in the time span 1970–97. Forty-two subjects (6%) were lost to follow-up and eight causes of death (4%) could not be ascertained. The overall mortality was not above the expected value. Among neoplastic diseases, excesses were observed for lung [standardized mortality ratio (SMR) = 124; 90% confidence interval (Cl) = 87–172; 26 obs), pleura (SMR = 1,327; Cl = 523–2,790; 5 obs), larynx (SMR = 240; Cl = 95–505; 5 obs), liver (SMR = 241; Cl = 126–420; 9 obs), pancreas (SMR = 224; Cl = 98–443; 6 obs) and multiple myeloma (SMR = 429; Cl = 117–1,109; 3 obs). The observed excess of lung and pleural neoplasms can be causally related to asbestos exposure in the manufacture of railway carriages. A causal role of asbestos exposure in the raised SMRs from laryngeal and pancreatic neoplasms and multiple myeloma cannot be conclusively proven. |
Handle: | http://hdl.handle.net/11365/17193 |
Appare nelle tipologie: | 1.1 Articolo in rivista |