We report a unique case of malignant transformation in a retinocytoma monitored using magnetic resonance imaging (MRI). This case is notable for a distinct drop in apparent diffusion coefficient (ADC) values that correlated with clinical transformation to retinoblastoma. This is the first report to highlight a change in ADC as a radiological marker of malignant conversion in retinocytoma. This finding suggests the potential role of ADC in prognostic assessment and risk stratification for patients with retinocytoma.
De Francesco, S., Galluzzi, P., Padula, T., Rubegni, G., De Marzo, P., Fruschelli, M., et al. (2026). The apparent diffusion coefficient as a potential radiological biomarker of malignant transformation in retinoblastoma: a case report. PEDIATRIC RADIOLOGY, 56(2), 477-480 [10.1007/s00247-025-06451-8].
The apparent diffusion coefficient as a potential radiological biomarker of malignant transformation in retinoblastoma: a case report
De Francesco, SoniaWriting – Review & Editing
;Padula, Tommaso
Writing – Original Draft Preparation
;Rubegni, GiovanniWriting – Review & Editing
;De Marzo, PierluigiMembro del Collaboration Group
;Fruschelli, MarioConceptualization
;Hadjistilianou, DorisSupervision
2026-01-01
Abstract
We report a unique case of malignant transformation in a retinocytoma monitored using magnetic resonance imaging (MRI). This case is notable for a distinct drop in apparent diffusion coefficient (ADC) values that correlated with clinical transformation to retinoblastoma. This is the first report to highlight a change in ADC as a radiological marker of malignant conversion in retinocytoma. This finding suggests the potential role of ADC in prognostic assessment and risk stratification for patients with retinocytoma.
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https://hdl.handle.net/11365/1321476
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