Neuroplasticity is shaped by how humans interact with AI. We argue that passive, uncritical, reliance on AI may weaken activity-dependent brain plasticity and erode cognition, whereas active co-creation can sustain or enhance it. Drawing on plasticity rules and ethical considerations, we propose the 3R principle—Results, Responses, Responsibility—as a preventive framework for cognitive hygiene, urging education towards AI use to preserve agency, meaning-making, and long-term brain health.
Rossi, S., Fraccaro, V., Manzotti, R. (2026). The brain side of human-AI interactions in the long-term: the “3R principle”. NPJ ARTIFICIAL INTELLIGENCE., 2(1) [10.1038/s44387-025-00063-1].
The brain side of human-AI interactions in the long-term: the “3R principle”
Rossi, Simone;
2026-01-01
Abstract
Neuroplasticity is shaped by how humans interact with AI. We argue that passive, uncritical, reliance on AI may weaken activity-dependent brain plasticity and erode cognition, whereas active co-creation can sustain or enhance it. Drawing on plasticity rules and ethical considerations, we propose the 3R principle—Results, Responses, Responsibility—as a preventive framework for cognitive hygiene, urging education towards AI use to preserve agency, meaning-making, and long-term brain health.
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https://hdl.handle.net/11365/1316214