Linee guida SIPMeL per la diagnosi e il monitoraggio della malattia celiaca: revisione 2025 SIPMeL guidelines for the diagnosis and monitoring of celiac disease: revision 2025.

This document updates the recommendations for the diagnosis and monitoring of celiac disease developed by the Study Group on Autoimmunology (GdS-AI) of the Italian Society of Clinical Pathology and Laboratory Medicine (SIPMeL), including innovative aspects and answering open questions regarding diagnostic strategies, issues related to the follow-up of patients on a gluten-free diet, the importance of biopsy in confirming the diagnosis and the role of genetic tests. The guidelines were developed after a systematic review of the most recent scientific literature and consist of 11 recommendations based on evidence that has emerged in recent years to guide the response to clinical questions and contribute to improving healthcare. The level of quality of evidence and the strength of recommendations were assigned according to the GRADE method, in order to apply a rigorous and transparent method for the production of effective and efficient diagnostic recommendations. © 2025 EDIZIONI MINERVA MEDICA.