Purpose:The aim of this study was to report the 12 to 96 months results of a tissue-preservation algorithm based on ray-tracing-guided transepithelial excimer laser central corneal ablation (RT t-PRK) combined with individualized pachymetry-guided accelerated crosslinking (M nomogram ACXL) in young adult patients with stable keratoconus (KC).Methods:This was a prospective interventional study including 38 eyes of 38 young adult patients (stage II KC) with a mean age of 35 years (range 26-46 years) who underwent simultaneous RT with t-PRK plus pachymetry-based ACXL in the worst eye. The treatments were performed using the iViS Suite iRES Excimer Laser (Ligi, Taranto, Italy). Ray-tracing-guided treatments were planned using the customized interactive programmed transepithelial ablation (CIPTA) 2 web software and diagnostic data were assessed by the Precisio 2 tomographer (Ligi, Taranto, Italy) and Sirius tomographer (C.S.O., Florence, Italy). The main outcome measures included uncorrected distance visual acuity, best spectacle-corrected visual acuity, Kmax, high-order aberrations, minimum corneal thickness, and posterior elevation, with a mean follow-up of 52 months (range 12-96 m).Results:The mean UDVA improved + 3.5 +/- 1.28 Snellen lines (SL); 38% gained >= 4 +/- 1.34 SLs, 35% >= 3 +/- 1.21 SLs, 22% >= 2 +/- 1.12 SLs, and 5% >= 1 +/- 0.75 SLs. The mean best spectacle-corrected visual acuity increased by + 4.3 +/- 1.3 SL. Sixty-eight percent gained >= 4 +/- 0.88 SLs and 30% >= 3 +/- 0.78 SL. No SLs were lost.Conclusions:RT t-PRK plus ACXL significantly improved the quality of vision in patients with KC, preventing overcorrection and minimizing tissue consumption.
Mazzotta, C., Stojanovic, A., Romano, V., Addabbo, G., Borroni, D., Balamoun, A.A., et al. (2024). Ray-Tracing Transepithelial Excimer Laser Central Corneal Remodeling Plus Pachymetry-Guided Accelerated Corneal Crosslinking for Keratoconus. CORNEA, 43(3), 285-294 [10.1097/ico.0000000000003380].
Ray-Tracing Transepithelial Excimer Laser Central Corneal Remodeling Plus Pachymetry-Guided Accelerated Corneal Crosslinking for Keratoconus
Mazzotta, Cosimo;
2024-01-01
Abstract
Purpose:The aim of this study was to report the 12 to 96 months results of a tissue-preservation algorithm based on ray-tracing-guided transepithelial excimer laser central corneal ablation (RT t-PRK) combined with individualized pachymetry-guided accelerated crosslinking (M nomogram ACXL) in young adult patients with stable keratoconus (KC).Methods:This was a prospective interventional study including 38 eyes of 38 young adult patients (stage II KC) with a mean age of 35 years (range 26-46 years) who underwent simultaneous RT with t-PRK plus pachymetry-based ACXL in the worst eye. The treatments were performed using the iViS Suite iRES Excimer Laser (Ligi, Taranto, Italy). Ray-tracing-guided treatments were planned using the customized interactive programmed transepithelial ablation (CIPTA) 2 web software and diagnostic data were assessed by the Precisio 2 tomographer (Ligi, Taranto, Italy) and Sirius tomographer (C.S.O., Florence, Italy). The main outcome measures included uncorrected distance visual acuity, best spectacle-corrected visual acuity, Kmax, high-order aberrations, minimum corneal thickness, and posterior elevation, with a mean follow-up of 52 months (range 12-96 m).Results:The mean UDVA improved + 3.5 +/- 1.28 Snellen lines (SL); 38% gained >= 4 +/- 1.34 SLs, 35% >= 3 +/- 1.21 SLs, 22% >= 2 +/- 1.12 SLs, and 5% >= 1 +/- 0.75 SLs. The mean best spectacle-corrected visual acuity increased by + 4.3 +/- 1.3 SL. Sixty-eight percent gained >= 4 +/- 0.88 SLs and 30% >= 3 +/- 0.78 SL. No SLs were lost.Conclusions:RT t-PRK plus ACXL significantly improved the quality of vision in patients with KC, preventing overcorrection and minimizing tissue consumption.File | Dimensione | Formato | |
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https://hdl.handle.net/11365/1255860