The prevalence of chronic heart failure (CHF) is steadily increasing. Both sexes are affected, with significant differences in etiology, epidemiology and clinical presentation, prognosis, comorbidities, and response to treatment. Women tend to develop CHF at a more advanced age, presentmore often with HF with preserved ejection fraction, are more symptomatic, and have a worse quality of life than men, but also a better prognosis. In women, CHF has more frequently a non-ischemic etiology, and arterial hypertension and diabetes mellitus are leading comorbidities. Furthermore, many sex-related differences have been detected in the response to treatment, for example a greater prognostic benefit from angiotensin-receptor blockers in women, a higher incidence of complications after defibrillator implantation, and a greater response to cardiac resynchronization therapy. Furthermore, women are less likely to receive defibrillator therapy or heart transplantation. The significant underrepresentation of women in clinical trials limits our capacity to evaluate the extent of sex-related differences in CHF, although their characterization seems crucial in order to achieve the ultimate goal of a tailored therapy for this condition. (C) 2017 Elsevier B.V. All rights reserved.

Aimo, A., Vergaro, G., Barison, A., Maffei, S., Borrelli, C., Morrone, D., et al. (2018). Sex-related differences in chronic heart failure. INTERNATIONAL JOURNAL OF CARDIOLOGY, 255, 145-151 [10.1016/j.ijcard.2017.10.068].

Sex-related differences in chronic heart failure

Maffei, Silvia;Cameli, Matteo;Palazzuoli, Alberto;Ambrosio, Giuseppe;Emdin, Michele
2018-01-01

Abstract

The prevalence of chronic heart failure (CHF) is steadily increasing. Both sexes are affected, with significant differences in etiology, epidemiology and clinical presentation, prognosis, comorbidities, and response to treatment. Women tend to develop CHF at a more advanced age, presentmore often with HF with preserved ejection fraction, are more symptomatic, and have a worse quality of life than men, but also a better prognosis. In women, CHF has more frequently a non-ischemic etiology, and arterial hypertension and diabetes mellitus are leading comorbidities. Furthermore, many sex-related differences have been detected in the response to treatment, for example a greater prognostic benefit from angiotensin-receptor blockers in women, a higher incidence of complications after defibrillator implantation, and a greater response to cardiac resynchronization therapy. Furthermore, women are less likely to receive defibrillator therapy or heart transplantation. The significant underrepresentation of women in clinical trials limits our capacity to evaluate the extent of sex-related differences in CHF, although their characterization seems crucial in order to achieve the ultimate goal of a tailored therapy for this condition. (C) 2017 Elsevier B.V. All rights reserved.
2018
Aimo, A., Vergaro, G., Barison, A., Maffei, S., Borrelli, C., Morrone, D., et al. (2018). Sex-related differences in chronic heart failure. INTERNATIONAL JOURNAL OF CARDIOLOGY, 255, 145-151 [10.1016/j.ijcard.2017.10.068].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/1237856
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