: The COVID-19 pandemic, caused by SARS-CoV-2, has caused an estimated 5 billion infections and 20 million deaths by respiratory failure. In addition to the respiratory disease, SARS-CoV-2 infection has been associated with many extrapulmonary complications not easily explainable by the respiratory infection. A recent study showed that the SARS-CoV-2 spike protein, which mediates cell entry by binding to the angiotensin-converting enzyme 2 (ACE2) receptor, signals through ACE2 to change host cell behavior. In CD8+ T cells, spike-dependent ACE2-mediated signaling suppresses immunological synapse (IS) formation and impairs their killing ability, leading to immune escape of virus-infected cells. In this opinion article, we discuss the consequences of ACE2 signaling on the immune response and propose that it contributes to the extrapulmonary manifestations of COVID-19.

Baldari, C.T., Onnis, A., Andreano, E., Del Giudice, G., Rappuoli, R. (2023). Emerging roles of SARS-CoV-2 Spike-ACE2 in immune evasion and pathogenesis. TRENDS IN IMMUNOLOGY [10.1016/j.it.2023.04.001].

Emerging roles of SARS-CoV-2 Spike-ACE2 in immune evasion and pathogenesis

Baldari, Cosima T
Writing – Original Draft Preparation
;
Onnis, Anna
Writing – Original Draft Preparation
;
Andreano, Emanuele
Writing – Original Draft Preparation
;
Rappuoli, Rino
2023-01-01

Abstract

: The COVID-19 pandemic, caused by SARS-CoV-2, has caused an estimated 5 billion infections and 20 million deaths by respiratory failure. In addition to the respiratory disease, SARS-CoV-2 infection has been associated with many extrapulmonary complications not easily explainable by the respiratory infection. A recent study showed that the SARS-CoV-2 spike protein, which mediates cell entry by binding to the angiotensin-converting enzyme 2 (ACE2) receptor, signals through ACE2 to change host cell behavior. In CD8+ T cells, spike-dependent ACE2-mediated signaling suppresses immunological synapse (IS) formation and impairs their killing ability, leading to immune escape of virus-infected cells. In this opinion article, we discuss the consequences of ACE2 signaling on the immune response and propose that it contributes to the extrapulmonary manifestations of COVID-19.
2023
Baldari, C.T., Onnis, A., Andreano, E., Del Giudice, G., Rappuoli, R. (2023). Emerging roles of SARS-CoV-2 Spike-ACE2 in immune evasion and pathogenesis. TRENDS IN IMMUNOLOGY [10.1016/j.it.2023.04.001].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/1232360
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