Monoclonal antibodies (mAbs) represent a promising class of therapeutics against bacterial pathogens, including those which are developing antimicrobial resistance (AMR). Functional, high-throughput assays, which investigate the ability of mAbs to kill bacteria or protect the host, are currently lacking. The aim of this PhD thesis was to establish high-content and high-throughput methods to screen and characterize functional mAbs against Neisseria gonorrhoeae.
Vacca, F. (2023). Development of image-based high content screening assays for testing monoclonal antibodies against Neisseria gonorrhoeae infecting human cells [10.25434/vacca-fabiola_phd2023].
Development of image-based high content screening assays for testing monoclonal antibodies against Neisseria gonorrhoeae infecting human cells
Vacca Fabiola
2023-01-01
Abstract
Monoclonal antibodies (mAbs) represent a promising class of therapeutics against bacterial pathogens, including those which are developing antimicrobial resistance (AMR). Functional, high-throughput assays, which investigate the ability of mAbs to kill bacteria or protect the host, are currently lacking. The aim of this PhD thesis was to establish high-content and high-throughput methods to screen and characterize functional mAbs against Neisseria gonorrhoeae.
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https://hdl.handle.net/11365/1232214