8 Tesi di dottorato

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Clinical and laboratory investigations on cervical margin relocation

In the presence of subgingival proximal margins, close to or below the cemento-enamel junction (CEJ), impression taking and adhesive luting procedures for indirect restorations are hampered; surgical crown lengthening or orthodontic eruption are viable options. However, the placement of a small amount of composite, so-called cervical margin relocation (CMR), was proposed as an alternative technique. To date, literature about CMR is scarce and the aim of this PhD thesis was to perform labora...

LA MISURAZIONE DEL VALORE DEL WELFARE CONTRATTUALE. UNA PROSPETTIVA DI RELAZIONI INDUSTRIALI

Dopo aver inquadrato l'oggetto dell'approfondimento dalla prospettiva del diritto delle relazioni industriali nella nuova Grande Trasformazione del Lavoro, attingendo al materiale negoziale (del settore privato e di quello pubblico, di primo e di secondo livello), lo studio propone una misurazione del valore (e dei Valori) del welfare contrattuale, elaborando all'uopo una metrica che possa orientare gli attori della rappresentanza verso soluzioni (collettive, ma) personalizzate, capaci di ris...

Serum neuronal, glial, and mitochondrial markers in autosomal dominant optic atrophy and Leber’s hereditary optic neuropathy

In this study, we investigated neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP), two biomarkers of neurodegeneration that have recently become easily measurable in serum due to the development of ultrasensitive digital immunoassay methods. Additionally, we analyzed growth/differentiation factor 15 (GDF-15), a well-established biomarker for primary mitochondrial diseases caused by defects in mitochondrial translation mechanisms and mitochondrial DNA integrity. Spe...

Evaluation of new gold-based nanoformulations for gene editing: in vitro and in vivo approaches for melanoma immunotherapy

The CRISPR/Cas9 gene-editing system holds immense potential for treating cancer and various diseases, as demonstrated in vitro and in animal models. However, its clinical application remains limited due to two major challenges: the inability to precisely control Cas9 activity in terms of location and duration. This study proposes two innovative gene-editing approaches to overcome these limitations. The first utilizes gold nanoparticles (AuNPs) conjugated to Cas9, enabling spontaneous cellular...

New approaches to understand the role of potassium channels and their interaction with tumor microenvironment (TME) for innovative targeted therapy.

The formation of fibrotic tissue around tumor cells, known as desmoplasia, represents a significant challenge in the treatment of pancreatic ductal adenocarcinoma (PDAC). As a significant source of tumor-promoting cells within the extracellular matrix (ECM), stellate cells and cancer-associated fibroblasts (CAFs) represent a promising contributory factor in tumor development. The dysfunction and aberrant expression of ion channels is implicated in the pathogenesis of numerous diseases, inclu...

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