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Il laudario di Iacopone da Todi. Saggio di edizione critica e studio linguistico dei manoscritti di Chantilly e Londra

The dissertation consists of a partial critical edition of Iacopone da Todi’s Laudario, and is a part of a research project that encompasses its complete edition. Within this project, coordinated by Professor Lino Leonardi, are also Andrea Giraudo and Giuseppina Orobello, both of whom have already obtained their PhD degrees with theses on Iacopone. These theses were supervised by Prof. Leonardi during cycles XXXII and XXXIII) within the Romance Philology curriculum – Filologia e Critica PhD p...

Circulating levels of vitamin D, vitamin B12, folate, homocysteine, and major haemato-chemical parameters in mood-disorder patients: a comparative cross-sectional study

The potential involvement of the immune and inflammatory systems, together alterations of their biochemical markers, has been extensively studied in mood disorders such as major depression and bipolar disorders. This topic in clinical research is currently providing important results. Indeed, an ever-growing body of evidence is showing the presence, within patients, of activated inflammatory patterns resulting from altered neurotransmission and abnormally regulated neuroendocrine response to ...

SYSTEMS BIOLOGY AND TRANSCRIPTOMIC ANALYSIS TO STUDY THE IMMUNE RESPONSE TO INFECTIONS AND VACCINES

Given the complexity of living systems, and the difficulty of measuring and interpreting data from these systems, biomedical science has been adopting a reductionist approach over the years. However, the rapid technological advances and the progress in molecular biology and computation are changing this establishment. Transcriptomics is one of the technologies that has revolutionized the way we study the response of organisms to various situations, such as infections, vaccines and cancer. By...

EXPLOITING MOLECULAR TARGETING IN ANTICANCER CHEMOTHERAPY: IN SILICO STUDIES TO IDENTIFY NOVEL MOLECULES TARGETING KINASES IN CONVERGENT METABOLIC PATHWAYS IN CANCER THERAPY

In recent years, a convergence of scientific progress has allowed to identify specific molecular targets and signaling routes for cancer cells, leading to more selective, more effective, and less toxic treatments. The validation of compounds was originally based on the validation of the target, despite some of the most effective drugs often have effects outside their hypothetical mechanism. Protein kinases have become interesting molecular targets and considerable research has targeted drugs ...

Non-Thermal Features in TeV-Blazars and the Galactic Center Region with MAGIC and Prospects for CTA

Our Universe is known to be the venue where extreme, powerful and violent phenomena occur in the most compact objects, interstellar and intergalactic space. Its non-thermal behaviour can be seen with the gamma eyes of space-based and ground-based telescopes, and the observations performed with these innovative instruments represent the novel research field of the Gamma-ray Astronomy. On the balance between the life-and-death in stars lies the presence of extremely energetic particles, the...

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