8 Tesi di dottorato

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Engineered small protein scaffold for a novel mesothelin-targeted therapy: a focus on pleural mesothelioma

In the last decades, targeted therapy has been proposed as a novel strategy to overcome tumor burden worldwide, exploiting monoclonal antibodies (mAbs, ~150 kDa) engineered to recognize tumor biomarkers for therapeutic purposes. Recently, small protein scaffolds have been also employed as targeting agents with similar functions of mAbs. Due to their molecular size (~10 kDa) and their biophysical properties, such protein structures can be used to improve drug delivery specifically in solid tum...

Changes in CLIMP63 expression alter the organization of the microtubule network of mouse skeletal muscle fibers

The endoplasmic reticulum (ER) is a highly specialized organelle, responsible for protein synthesis and Ca2+ handling. It establishes contacts with several other organelles and is closely associated with microtubules (MTs). MTs act as a scaffold for ER positioning and remodeling, playing a central role in ER morphogenesis. In skeletal muscle, the sarcoplasmic reticulum (SR) is a specialization of the ER, dedicated to Ca2+ storage and release necessary for muscle contraction. Recent data sug...

From tanneries solid waste to catalysis

Hydroformylation and Hydroaminomethylation are among the most applied catalytic process in industry worldwide, being efficient atom-economic reactions for the synthesis of aldehydes and amines from olefines. We report here a sustainable and generally appliable protocols for the regioselective hydroaminomethylation of terminal alkenes in water, taking advantage from both micellar and microwave catalysis which sustainability was studied trough a Life Cycle Assessment (LCA) analysis in compariso...

Study of the Nutraceutical Properties of Tuscan Functional Foods such as Extra Virgin Olive Oil through a Multidisciplinary Approach Based on Big Data Analysis, Target Fishing and Artificial Intelligence Models

This dissertation investigates the nutraceutical potential of Tuscan functional foods, focusing on extra virgin olive oil (EVOO) bioactives, including the novel lignan 1-acetoxypinoresinol (1-AP), and fermented cereals. This work introduces in silico nutraceutical target fishing (Nutrafishing) as a novel approach in this field. The first chapter provides a general introduction and background for the subsequent studies. The second chapter presents the first comprehensive review of 1-AP, synthe...

The effect of metabolic imbalance in the retina and beyond: new insights from the role of antioxidants, thyroid hormones and β3-adrenoceptor

The study of the molecular mechanisms underlying the pathological processes induced by metabolic imbalance could provide important insights for the development of novel therapeutic strategies to counteract the onset of diseases in particularly sensitive tissues. The high energy demand required by retinal neurons renders them highly susceptible to various metabolic stressors, inducing imbalanced metabolism-related pathological processes such as oxidative stress and inflammation, then triggerin...

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