The Helicobacter pylon HP-NAP is a dodecameric protein with a three-dimensional structure similar to that of bacterioferritins. Originally defined as neutrophil-activating protein, because of its ability to stimulate neutrophils to produce oxygen radicals, HP-NAP is now considered a crucial factor in driving the Th1 inflammation in H. pylori infection. This review summarizes recent studies that have provided a deeper understanding of the pro-inflammatory and immune modulatory properties of HP-NAP. We first examine the role of this protein in the H. pylori-associated disease, and then we discuss recent findings that support the possibility for HP-NAP to become a new tool for therapeutic strategies aimed at redirecting Th2 into Th1 responses, for example in atopy, vaccinology and cancer immunotherapy. (C) 2009 Elsevier Ltd. All rights reserved.
de Bernard, M., D'Elios, M.M. (2010). The immune modulating activity of the Helicobacter pylori HP-NAP: Friend or foe?. TOXICON, 56(7), 1186-1192 [10.1016/j.toxicon.2009.09.020].
The immune modulating activity of the Helicobacter pylori HP-NAP: Friend or foe?
D'Elios, Mario M.
2010-01-01
Abstract
The Helicobacter pylon HP-NAP is a dodecameric protein with a three-dimensional structure similar to that of bacterioferritins. Originally defined as neutrophil-activating protein, because of its ability to stimulate neutrophils to produce oxygen radicals, HP-NAP is now considered a crucial factor in driving the Th1 inflammation in H. pylori infection. This review summarizes recent studies that have provided a deeper understanding of the pro-inflammatory and immune modulatory properties of HP-NAP. We first examine the role of this protein in the H. pylori-associated disease, and then we discuss recent findings that support the possibility for HP-NAP to become a new tool for therapeutic strategies aimed at redirecting Th2 into Th1 responses, for example in atopy, vaccinology and cancer immunotherapy. (C) 2009 Elsevier Ltd. All rights reserved.File | Dimensione | Formato | |
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https://hdl.handle.net/11365/1220682