In order to assess the mechanism of action of the quinoline-3-carboxyamide linomide as an antiangiogenic drug, the effect of linomide was studied in vitro on postcapillary endothelial cells exposed to vascular endothelial growth factor (VEGF). Linomide did not block the spontaneous replication of endothelial cells, but significantly suppressed endothelial cell growth and migration elicited by VEGF. It is concluded that linomide appears to be an effective tool to inhibit VEGF-dependent angiogenesis

Parenti, A., Donnini, S., Morbidelli, L., Granger, H.J., Ziche, M. (1996). The effect of linomide on the migration and the proliferation of capillary endothelial cells elicited by vascular endothelial growth factor. BRITISH JOURNAL OF PHARMACOLOGY, 119(4), 619-621 [10.1111/j.1476-5381.1996.tb15718.x].

The effect of linomide on the migration and the proliferation of capillary endothelial cells elicited by vascular endothelial growth factor

Parenti, A.;Donnini, Sandra;Morbidelli, Lucia;Ziche, Marina
1996-01-01

Abstract

In order to assess the mechanism of action of the quinoline-3-carboxyamide linomide as an antiangiogenic drug, the effect of linomide was studied in vitro on postcapillary endothelial cells exposed to vascular endothelial growth factor (VEGF). Linomide did not block the spontaneous replication of endothelial cells, but significantly suppressed endothelial cell growth and migration elicited by VEGF. It is concluded that linomide appears to be an effective tool to inhibit VEGF-dependent angiogenesis
1996
Parenti, A., Donnini, S., Morbidelli, L., Granger, H.J., Ziche, M. (1996). The effect of linomide on the migration and the proliferation of capillary endothelial cells elicited by vascular endothelial growth factor. BRITISH JOURNAL OF PHARMACOLOGY, 119(4), 619-621 [10.1111/j.1476-5381.1996.tb15718.x].
File in questo prodotto:
File Dimensione Formato  
brjpharm1996.pdf

non disponibili

Tipologia: Post-print
Licenza: NON PUBBLICO - Accesso privato/ristretto
Dimensione 432.75 kB
Formato Adobe PDF
432.75 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/12122
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo