The sarcoplasmic reticulum of skeletal muscle cells is a highly ordered structure consisting of an intricate network of tubules and cisternae specialized for regulating Ca2+ homeostasis in the context of muscle contraction. The sarcoplasmic reticulum contains several proteins, some of which support Ca2+ storage and release, while others regulate the formation and maintenance of this highly convoluted organelle and mediate the interaction with other components of the muscle fiber. In this review, some of the main issues concerning the biology of the sarcoplasmic reticulum will be described and discussed; particular attention will be addressed to the structure and function of the two domains of the sarcoplasmic reticulum supporting the excitation–contraction coupling and Ca2+-uptake mechanisms.

Rossi, D., Pierantozzi, E., Amadsun, D.O., Buonocore, S., Rubino, E.M., Sorrentino, V. (2022). The Sarcoplasmic Reticulum of Skeletal Muscle Cells: A Labyrinth of Membrane Contact Sites. BIOMOLECULES, 12(4) [10.3390/biom12040488].

The Sarcoplasmic Reticulum of Skeletal Muscle Cells: A Labyrinth of Membrane Contact Sites

Rossi, Daniela
Writing – Original Draft Preparation
;
Pierantozzi, Enrico
Supervision
;
Amadsun, David Osamwonuyi
Writing – Original Draft Preparation
;
Buonocore, Sara
Writing – Original Draft Preparation
;
Rubino, Egidio Maria
Writing – Original Draft Preparation
;
Sorrentino, Vincenzo
Writing – Review & Editing
2022-01-01

Abstract

The sarcoplasmic reticulum of skeletal muscle cells is a highly ordered structure consisting of an intricate network of tubules and cisternae specialized for regulating Ca2+ homeostasis in the context of muscle contraction. The sarcoplasmic reticulum contains several proteins, some of which support Ca2+ storage and release, while others regulate the formation and maintenance of this highly convoluted organelle and mediate the interaction with other components of the muscle fiber. In this review, some of the main issues concerning the biology of the sarcoplasmic reticulum will be described and discussed; particular attention will be addressed to the structure and function of the two domains of the sarcoplasmic reticulum supporting the excitation–contraction coupling and Ca2+-uptake mechanisms.
Rossi, D., Pierantozzi, E., Amadsun, D.O., Buonocore, S., Rubino, E.M., Sorrentino, V. (2022). The Sarcoplasmic Reticulum of Skeletal Muscle Cells: A Labyrinth of Membrane Contact Sites. BIOMOLECULES, 12(4) [10.3390/biom12040488].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/1198547