Desingning experiments to optimize and validate the absorptive stripping voltammetric determination of nimesulide

The development and validation, by experimental design, of an adsorptive stripping voltammetric procedure for nimesulide determination is described. A Plackett-Burman matrix and a Doehlert design were used for the screening step and response surface study, respectively. Response surface evaluation allowed the method to be defined robust and robustness testing was considered unnecessary. A full factorial design was employed for intermediate precision determination according to ICH guidelines. Applying the optimised conditions, the linear range was 3.32x10-9-3.85x10-7M and the dosage form mean recovery was 101.3% with RSD of 1.3% (n=9). Copyright (C) 2000 Elsevier Science B.V.