Previous studies have reported an association between anti-tumor necrosis factor alpha (anti-TNFα) treatment and central nervous system (CNS) events. We described eight patients presenting with demyelinating CNS events while on treatment with anti-TNFα for autoimmune diseases and followed up for a medium period of 4 years. Four patients presented with isolated demyelinating events, three patients fulfilled the criteria for multiple sclerosis (MS), and one patient showed worsening of pre-existing MS after anti-TNF therapy initiation. All patients except one, showed a good medium-term prognosis. Our observation supports an association between anti-TNFα treatment and demyelinating events and suggests that a prompt discontinuation of the drug may lead to a favorable demyelinating disease outcome.

Cortese, R., Prosperini, L., Stasolla, A., Haggiag, S., Villani, V., Simone, I.L., et al. (2021). Clinical course of central nervous system demyelinating neurological adverse events associated with anti-TNF therapy. JOURNAL OF NEUROLOGY, 268(8), 2895-2899 [10.1007/s00415-021-10460-6].

Clinical course of central nervous system demyelinating neurological adverse events associated with anti-TNF therapy

Cortese R.;
2021-01-01

Abstract

Previous studies have reported an association between anti-tumor necrosis factor alpha (anti-TNFα) treatment and central nervous system (CNS) events. We described eight patients presenting with demyelinating CNS events while on treatment with anti-TNFα for autoimmune diseases and followed up for a medium period of 4 years. Four patients presented with isolated demyelinating events, three patients fulfilled the criteria for multiple sclerosis (MS), and one patient showed worsening of pre-existing MS after anti-TNF therapy initiation. All patients except one, showed a good medium-term prognosis. Our observation supports an association between anti-TNFα treatment and demyelinating events and suggests that a prompt discontinuation of the drug may lead to a favorable demyelinating disease outcome.
2021
Cortese, R., Prosperini, L., Stasolla, A., Haggiag, S., Villani, V., Simone, I.L., et al. (2021). Clinical course of central nervous system demyelinating neurological adverse events associated with anti-TNF therapy. JOURNAL OF NEUROLOGY, 268(8), 2895-2899 [10.1007/s00415-021-10460-6].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/1192012
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