The mechanisms responsible for the favorable clinical course in multiple sclerosis (MS) remain unclear. In this longitudinal study, we assessed whether magnetic resonance imaging (MRI)-based changes in focal and diffuse brain damage are associated with a long-term favorable MS diseases course. We found that global brain and gray matter (GM) atrophy changes were milder in MS patients with long-standing disease (⩾30 years from onset) and favorable (no/minimal disability) clinical course than in sex-age-matched disable MS patients, independently of lesions accumulation. Data showed that different trajectories of volume changes, as reflected by mild GM atrophy, may characterize patients with long-term favorable evolution.

Cortese, R., Battaglini, M., Parodi, F., Stromillo, M.L., Portaccio, E., Razzolini, L., et al. (2022). Mild gray matter atrophy in patients with long-standing multiple sclerosis and favorable clinical course. MULTIPLE SCLEROSIS, 28(1), 154-159 [10.1177/13524585211019650].

Mild gray matter atrophy in patients with long-standing multiple sclerosis and favorable clinical course

Cortese R.;Battaglini M.;Parodi F.;Stromillo M. L.;Giorgio A.;De Stefano N.
2022-01-01

Abstract

The mechanisms responsible for the favorable clinical course in multiple sclerosis (MS) remain unclear. In this longitudinal study, we assessed whether magnetic resonance imaging (MRI)-based changes in focal and diffuse brain damage are associated with a long-term favorable MS diseases course. We found that global brain and gray matter (GM) atrophy changes were milder in MS patients with long-standing disease (⩾30 years from onset) and favorable (no/minimal disability) clinical course than in sex-age-matched disable MS patients, independently of lesions accumulation. Data showed that different trajectories of volume changes, as reflected by mild GM atrophy, may characterize patients with long-term favorable evolution.
Cortese, R., Battaglini, M., Parodi, F., Stromillo, M.L., Portaccio, E., Razzolini, L., et al. (2022). Mild gray matter atrophy in patients with long-standing multiple sclerosis and favorable clinical course. MULTIPLE SCLEROSIS, 28(1), 154-159 [10.1177/13524585211019650].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/1192010
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