A diffusion cell with an artificial membrane and the single-pass perfused rabbit ear were used to evaluate the percutaneous absorption of clonazepam from various 2-hydroxyethyl acetate (HEA) patches. The influence on drug permeation of the various type of enhancers (isopropylmyristate, lauryl alcohol, propylene glycol and water) in the patches was tested. A comparison between the two types of systems of percutaneuos absorption of clonazepam has been done. The results showed that HEA patches produce controlled uniform drug release, modulated by the addition of enhancers.
Corti, P., Dreassi, E., Mura, P., Perruccio, P.L. (1998). In vitro studies of simulated percutaneous absorption: influence of various enhancers in the release of clonazepam from 2-hydroxyethyl acetate patches. PHARMACEUTICA ACTA HELVETIAE, 72(5), 263-269 [10.1016/S0031-6865(97)00022-8].
In vitro studies of simulated percutaneous absorption: influence of various enhancers in the release of clonazepam from 2-hydroxyethyl acetate patches
Corti P.;Dreassi E.;
1998-01-01
Abstract
A diffusion cell with an artificial membrane and the single-pass perfused rabbit ear were used to evaluate the percutaneous absorption of clonazepam from various 2-hydroxyethyl acetate (HEA) patches. The influence on drug permeation of the various type of enhancers (isopropylmyristate, lauryl alcohol, propylene glycol and water) in the patches was tested. A comparison between the two types of systems of percutaneuos absorption of clonazepam has been done. The results showed that HEA patches produce controlled uniform drug release, modulated by the addition of enhancers.
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https://hdl.handle.net/11365/11906
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