Negative or positive HPV-associated Head and Neck Squamous Cell Carcinomas (HNSCCs) are high recurrence neoplasms usually resulting in a poor prognosis, mainly due to metastasis formation. Despite the low overall patient survival rate and the severe side effects, the treatment of choice is still cisplatin-based chemotherapy. Here, we report a straightforward protocol for the production of high throughput 3D models of negative or positive HPV-associated HNSCCs, together with their employment in the therapeutic evaluation of gold ultrasmall-in-nano architectures comprising an endogenously-activatable cisplatin prodrug. Beyond enhancing the biosafety of cisplatin, our approach paves the way for the establishment of synergistic co-therapies for HNSCCs based on excretable noble metals. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
Melissa, S., Ana Katrina, M., Domenico, C., Vlamidis, Y., Valentina, C., Valerio, V. (2020). Endogenously-activated ultrasmall-in-nano therapeutics: Assessment on 3d head and neck squamous cell carcinomas. CANCERS, 12(5) [10.3390/cancers12051063].
Endogenously-activated ultrasmall-in-nano therapeutics: Assessment on 3d head and neck squamous cell carcinomas
Vlamidis YValidation
;
2020-01-01
Abstract
Negative or positive HPV-associated Head and Neck Squamous Cell Carcinomas (HNSCCs) are high recurrence neoplasms usually resulting in a poor prognosis, mainly due to metastasis formation. Despite the low overall patient survival rate and the severe side effects, the treatment of choice is still cisplatin-based chemotherapy. Here, we report a straightforward protocol for the production of high throughput 3D models of negative or positive HPV-associated HNSCCs, together with their employment in the therapeutic evaluation of gold ultrasmall-in-nano architectures comprising an endogenously-activatable cisplatin prodrug. Beyond enhancing the biosafety of cisplatin, our approach paves the way for the establishment of synergistic co-therapies for HNSCCs based on excretable noble metals. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.File | Dimensione | Formato | |
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https://hdl.handle.net/11365/1187516