In this retrospective case-control study, we compared the number of circulating lymphocyte subsets among 31 healthy controls, 18 naïve and 40 antiretroviral-treated HIV patients, 28 untreated and 18 treated relapsing-remitting multiple sclerosis (MS) patients. Lymphocyte subsets were no different between untreated MS patients and controls. Untreated and treated MS had a lower CD8+ count and a higher CD4+ number compared to untreated and treated HIV patients except similar CD4+ number between treated MS and HIV patients. CD4/CD8 ratio was lower in female HIV non-responders and in relapsing MS women compared, respectively, to female HIV responders and remitting MS women, and there were no differences in men.
Koudriavtseva, T., Plantone, D., Mandoj, C., Giannarelli, D., Latini, A., Colafigli, M., et al. (2017). HIV and decreased risk of multiple sclerosis: role of low CD4+ lymphocyte count and male prevalence. JOURNAL OF NEUROVIROLOGY(23), 147-151 [10.1007/s13365-016-0471-2].
HIV and decreased risk of multiple sclerosis: role of low CD4+ lymphocyte count and male prevalence
Plantone D;
2017-01-01
Abstract
In this retrospective case-control study, we compared the number of circulating lymphocyte subsets among 31 healthy controls, 18 naïve and 40 antiretroviral-treated HIV patients, 28 untreated and 18 treated relapsing-remitting multiple sclerosis (MS) patients. Lymphocyte subsets were no different between untreated MS patients and controls. Untreated and treated MS had a lower CD8+ count and a higher CD4+ number compared to untreated and treated HIV patients except similar CD4+ number between treated MS and HIV patients. CD4/CD8 ratio was lower in female HIV non-responders and in relapsing MS women compared, respectively, to female HIV responders and remitting MS women, and there were no differences in men.File | Dimensione | Formato | |
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https://hdl.handle.net/11365/1153068