The aim of the study was to evaluate the type-1 immune response by analyzing T-bet expression in circulating T and B cells in Primary Progressive (PP) and Secondary Progressive (SP) Multiple Sclerosis (MS) patients. We found higher percentages of circulating CD4(+)T-bet(+) and CD8(+)T-bet(+) T cells in SPMS and PPMS than in remitting-relapsing MS patients and controls. Moreover, in SPMS, we observed a positive correlation between the percentages of circulating CD4(+)T-bet(+) or CD8(+)T-bet(+) T cells and disease severity. The increased percentages of Th1 and Tc1 cells suggest that MS progressive forms, unlike RRMS, are characterized by a permanent peripheral type-1 immune activation. (C) 2012 Elsevier B.V. All rights reserved.
Frisullo, G., Plantone, D., Marti, A., Iorio, R., Damato, V., Nociti, V., et al. (2012). Type 1 immune response in progressive multiple sclerosis. JOURNAL OF NEUROIMMUNOLOGY, 249(1-2), 112-116 [10.1016/j.jneuroim.2012.04.019].
Type 1 immune response in progressive multiple sclerosis
Plantone D;
2012-01-01
Abstract
The aim of the study was to evaluate the type-1 immune response by analyzing T-bet expression in circulating T and B cells in Primary Progressive (PP) and Secondary Progressive (SP) Multiple Sclerosis (MS) patients. We found higher percentages of circulating CD4(+)T-bet(+) and CD8(+)T-bet(+) T cells in SPMS and PPMS than in remitting-relapsing MS patients and controls. Moreover, in SPMS, we observed a positive correlation between the percentages of circulating CD4(+)T-bet(+) or CD8(+)T-bet(+) T cells and disease severity. The increased percentages of Th1 and Tc1 cells suggest that MS progressive forms, unlike RRMS, are characterized by a permanent peripheral type-1 immune activation. (C) 2012 Elsevier B.V. All rights reserved.File | Dimensione | Formato | |
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https://hdl.handle.net/11365/1152708