Until now, only one gestational tumefactive demyelinating lesion (TDL) has been described. Here we report two TDL cases occurring during and after the pregnancy. A 26-year-old 6-week pregnant woman developed a 3-cm left frontotemporoparietal subcortical TDL with inhomogeneous partial enhancement. Brain biopsy revealed a subacute demyelinating lesion with abundant macrophages and mild chronic perivascular inflammatory infiltrates. She also had femoralpopliteal deep vein thrombosis. During the 4-year follow-up, magnetic resonance imaging showed only residual biopsied TDL. The second case was a 41-year-woman affected by both multiple sclerosis (MS) and rheumatoid arthritis who developed a 2-cm right anterior corona radiata TDL with sporadic gadolinium-enhancing “annular spots” eight months after delivery. After steroid therapy at the 6-month radiological follow-up, this TDL was half-reduced. Five years earlier, at the beginning of her MS, she already had a 2-cm TDL with incomplete ring enhancement. These two described TDLs formed in prothrombotic conditions and were likely representative of thromboinflammation around and inside the smallmedium veins.
Plantone, D., Piantadosi, C., Ruggieri, S., Anelli, V., & Koudriavtseva, T. (2019). Tumefactive Demyelinating Lesions and Pregnancy. NEUROLOGY INDIA, 67(6), 1519-1521 [10.4103/0028-3886.273654].
|Titolo:||Tumefactive Demyelinating Lesions and Pregnancy|
|Citazione:||Plantone, D., Piantadosi, C., Ruggieri, S., Anelli, V., & Koudriavtseva, T. (2019). Tumefactive Demyelinating Lesions and Pregnancy. NEUROLOGY INDIA, 67(6), 1519-1521 [10.4103/0028-3886.273654].|
|Appare nelle tipologie:||1.1 Articolo in rivista|
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|Tumefactive Demyelinating Lesions and Pregnancy :Domenico Plantone1<:sup>, Carlo Piantadosi2<:sup>, Serena Ruggieri3<:sup>, Vincenzo Anelli4<:sup>, Tatiana Koudriavtseva5<:sup>, <:b>, Neurololy India.pdf||PDF editoriale||PUBBLICO - Pubblico con Copyright||Open Access Visualizza/Apri|