Relapsing-remitting multiple sclerosis (RRMS), secondary progressive (SP)MS and primary progressive (PP)MS patients showed higher percentages of circulating CD8(+)CD56(-)perforin(+) T cells than controls whereas only relapsing RRMS and PPMS patients showed higher perforin expression in CD8(+)CD56(-) T cells than controls. MS patients with EDSS >= 3 showed higher percentage of CD8(+)CD56(-)perforin(+) T cells than patients with EDSS <3 and controls whereas patients with EDSS <3 showed higher percentage of this T cell subpopulation than controls. Our data show that MS is characterized by a dysregulation of CD8(+)CD56(-)perforin(+) T cells that may play a role in the development of disability. (C) 2011 Elsevier B.V. All rights reserved.
Frisullo, G., Plantone, D., Marti, A., Raffaele, I., Nociti, V., Patanella, A.k., et al. (2011). Circulating CD8(+)CD56(-)perforin(+) T cells are increased in multiple sclerosis patients. JOURNAL OF NEUROIMMUNOLOGY, 240, 137-141 [10.1016/j.jneuroim.2011.09.002].
Circulating CD8(+)CD56(-)perforin(+) T cells are increased in multiple sclerosis patients
Plantone D;
2011-01-01
Abstract
Relapsing-remitting multiple sclerosis (RRMS), secondary progressive (SP)MS and primary progressive (PP)MS patients showed higher percentages of circulating CD8(+)CD56(-)perforin(+) T cells than controls whereas only relapsing RRMS and PPMS patients showed higher perforin expression in CD8(+)CD56(-) T cells than controls. MS patients with EDSS >= 3 showed higher percentage of CD8(+)CD56(-)perforin(+) T cells than patients with EDSS <3 and controls whereas patients with EDSS <3 showed higher percentage of this T cell subpopulation than controls. Our data show that MS is characterized by a dysregulation of CD8(+)CD56(-)perforin(+) T cells that may play a role in the development of disability. (C) 2011 Elsevier B.V. All rights reserved.File | Dimensione | Formato | |
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https://hdl.handle.net/11365/1152674