We investigated the immunohistochemical expression of bcl-2 in 55 non small cell lung cancer patients in order to understand if the altered expression of this gene is involved in the development of this kind of neoplasm. Our results showed bcl-2 immunopositivity to be a frequent event in small cell lung cancer (54.5%) with a higher expression in squamous carcinoma compared to adenocarcinoma (p = .04). In addition, we found a positive correlation between bcl-2 expression levels and nodal status (p < .003). We suggest that bcl-2 immunostaining could be considered as marker of loco-regional invasivity.
Greger, A.M., Caputi, M., Esposito, V., DE LUCA, A., Salat, A., Murabito, M., et al. (1999). BCL-2 protein expression correlates with nodal status in non small cell lung cancer. ANTICANCER RESEARCH, 19(1B), 821-824.
BCL-2 protein expression correlates with nodal status in non small cell lung cancer
GIORDANO A.;
1999-01-01
Abstract
We investigated the immunohistochemical expression of bcl-2 in 55 non small cell lung cancer patients in order to understand if the altered expression of this gene is involved in the development of this kind of neoplasm. Our results showed bcl-2 immunopositivity to be a frequent event in small cell lung cancer (54.5%) with a higher expression in squamous carcinoma compared to adenocarcinoma (p = .04). In addition, we found a positive correlation between bcl-2 expression levels and nodal status (p < .003). We suggest that bcl-2 immunostaining could be considered as marker of loco-regional invasivity.
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https://hdl.handle.net/11365/11440
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