Belladine N-oxides active against influenza A virus have been synthetized by a novel laccase-catalyzed 1,4-dioxane-mediated oxidation of aromatic and side-chain modified belladine derivatives. Electron paramagnetic resonance (EPR) analysis confirmed the role of 1,4-dioxane as a co-oxidant. The reaction was chemo-selective, showing a high functional-group compatibility. The novel belladine N-oxides were active against influenza A virus, involving the early stage of the virus replication life cycle.
Zippilli, C., Botta, L., Mattia Bizzarri, B., Nencioni, L., De Angelis, M., Protto, V., et al. (2021). Laccase-Catalyzed 1,4-Dioxane-Mediated synthesis of Belladine N-Oxides with anti-influenza a virus activity. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(3), 1-14 [10.3390/ijms22031337].
Laccase-Catalyzed 1,4-Dioxane-Mediated synthesis of Belladine N-Oxides with anti-influenza a virus activity
Gianluca Giorgi;Maria Camilla Baratto;Rebecca Pogni;
2021-01-01
Abstract
Belladine N-oxides active against influenza A virus have been synthetized by a novel laccase-catalyzed 1,4-dioxane-mediated oxidation of aromatic and side-chain modified belladine derivatives. Electron paramagnetic resonance (EPR) analysis confirmed the role of 1,4-dioxane as a co-oxidant. The reaction was chemo-selective, showing a high functional-group compatibility. The novel belladine N-oxides were active against influenza A virus, involving the early stage of the virus replication life cycle.
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https://hdl.handle.net/11365/1142365