Parallel analysis of peripheral blood mononuclear cell DNA and plasma RNA from 169 drug-naive human immunodeficiency virus-infected subjects revealed that evaluation of both compartments increases the sensitivity of detection of drug resistance-related mutations, compared with examination of either source alone. Peripheral blood mononuclear cell DNA may play a role in the surveillance of transmitted antiretroviral resistance.
Vicenti, I., Razzolini, F., Saladini, F., Romano, L., Zazzi, M. (2007). Use of peripheral blood DNA for genotypic antiretroviral resistance testing in drug-naïve HIV-infected subjects. CLINICAL INFECTIOUS DISEASES, 44(12), 1657-1661 [10.1086/518287].
Use of peripheral blood DNA for genotypic antiretroviral resistance testing in drug-naïve HIV-infected subjects.
VICENTI, ILARIA;RAZZOLINI, FRANCESCA;SALADINI, FRANCESCO;ROMANO, LAURA;ZAZZI, MAURIZIO
2007-01-01
Abstract
Parallel analysis of peripheral blood mononuclear cell DNA and plasma RNA from 169 drug-naive human immunodeficiency virus-infected subjects revealed that evaluation of both compartments increases the sensitivity of detection of drug resistance-related mutations, compared with examination of either source alone. Peripheral blood mononuclear cell DNA may play a role in the surveillance of transmitted antiretroviral resistance.
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https://hdl.handle.net/11365/11341
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