Correction: CXCR4/YY1 inhibition impairs VEGF network and angiogenesis during malignancy (Proceedings of the National Academy of Sciences of the United States of America (2010) 107 (14484–14489) DOI: 10.1073/pnas.1008256107)

PHARMACOLOGY Correction for “CXCR4/YY1 inhibition impairs VEGF network and angiogenesis during malignancy,” by Filomena de Nigris, Valeria Crudele, Alfonso Giovane, Amelia Casamassimi, Antonio Giordano, Hermes J. Garban, Francesco Cacciatore, Francesca Pentimalli, Diana C. Marquez-Garban, Antonella Petrillo, Letizia Cito, Linda Sommese, Andrea Fiore, Mario Petrillo, Alfredo Siani, Antonio Barbieri, Claudio Arra, Franco Rengo, Toshio Hayashi, Mohammed Al-Omran, Louis J. Ignarro, and Claudio Napoli, which was first published July 26, 2010; 10.1073/pnas.1008256107 (Proc Natl Acad Sci USA 107:14484–14489). The authors wish to note the following: “Concerns about the presentation of data in some of the figures in our paper were brought to our attention. During the process of data checking by international ALCOA parameters, we detected mistakes during figure preparation of some in vitro results in Figs. 3B and 5 A and C and Fig. S3. We have been able to find many original autoradiographs to confirm the results reported in our paper. We apologize for the inconvenience for these honest errors, which, importantly, do not affect the main results of the study. “In Fig. 3B, the first two bands of the VEGFB box look very similar, but at higher resolution, the bands are different. The original autoradiograph was found and the bands were presented in a horizontally inverted form during image assembly. In the VEGFC box, the first, second, and fourth bands look identical. During image assembly (cut and flipping the image) a copy of band 1 was inadvertently used instead of the correct image of band 4. “In Fig. 5A, we admit similarity of the bands in the ERK 1/2 gel; however, we recovered another experiment performed at the same time as data reported in the paper showing that, in our experimental conditions, ERK protein expression did not change during the time-course experiment. “In Fig. 5C, we admit to poor quality resolution of the published image and the appearance of two similar though irrelevant bands in the first two lanes. We apologize for the mistake due to erroneous duplication of bands during figure assembly. Data from other experiments performed at the time confirm the results and are used in the corrected figure. “In Fig. S3, we inadvertently duplicated the panel of VEGFB for VEGFD and GADPH, but have found the correct original images, which confirmed our results.” The editors have reviewed the data from the authors and the corrected Fig. 3, Fig. 5, and Fig. S3, and their legends, appear below. (Figure presented).