Aims/Background: The development of colorectal cancer depends on at least two distinct pathways involving genetic instability, namely: chromosome instability (CIN) and microsatellite instability. Cyclin E is involved in aneuploidy and several cancer types show an abnormal number of chromosomes. Methods: Cyclin E protein and mRNA values were analysed in human fetal skin fibroblasts and five colorectal cancer cell lines. Results: Cells with an aberrant number of chromosomes had higher cyclin E mRNA values and a significant increase in protein concentrations. Conclusions: These data suggest that cyclin E regulation is altered in aneuploid cells and is an important factor in the CIN pathway.
Simone, C., Resta, N., Bagella, L., Giordano, A., Guanti, G. (2002). Cyclin E and chromosome instability in colorectal cancer cell lines. MP. MOLECULAR PATHOLOGY, 55(3), 200-203 [10.1136/mp.55.3.200].
Cyclin E and chromosome instability in colorectal cancer cell lines
Giordano A.;
2002-01-01
Abstract
Aims/Background: The development of colorectal cancer depends on at least two distinct pathways involving genetic instability, namely: chromosome instability (CIN) and microsatellite instability. Cyclin E is involved in aneuploidy and several cancer types show an abnormal number of chromosomes. Methods: Cyclin E protein and mRNA values were analysed in human fetal skin fibroblasts and five colorectal cancer cell lines. Results: Cells with an aberrant number of chromosomes had higher cyclin E mRNA values and a significant increase in protein concentrations. Conclusions: These data suggest that cyclin E regulation is altered in aneuploid cells and is an important factor in the CIN pathway.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
https://hdl.handle.net/11365/1129313
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