Aim: To evaluate survival and toxicity in a cohort of patients treated with stereotactic body radiation therapy (SBRT) for unresectable intrahepatic malignancies. Patients and Methods: From 2007 to 2014, 23 patients with 34 lesions (three primary and 31 metastatic liver tumors) were treated with SBRT. Results: The median follow-up was 9 months (range=1-76) for all patients. Local control was reached in 27 out of 34 (79%) treated lesions, with 1 and 2 years rates of 93% and 73%, respectively. The progression-free survival at 1-year and 2-year was 50% and 25%, respectively. Median overall survival was 16 months (95% confidence interval=8-24 months), with 1-year and 2-year rates of 58% and 41%, respectively. Toxicity was very low consisting mainly of grade 1 and 2 events. Conclusion: SBRT provides good local control for both primary and metastatic liver lesions, with minimal toxicity.

Caivano, D., Bracci, S., Russo, I., Montalto, A., Armosini, V., De Sanctis, V., et al. (2015). Stereotactic body radiation therapy for liver lesions. A single-institution experience. ANTICANCER RESEARCH, 35(7), 4171-4176.

Stereotactic body radiation therapy for liver lesions. A single-institution experience

Minniti G.;
2015-01-01

Abstract

Aim: To evaluate survival and toxicity in a cohort of patients treated with stereotactic body radiation therapy (SBRT) for unresectable intrahepatic malignancies. Patients and Methods: From 2007 to 2014, 23 patients with 34 lesions (three primary and 31 metastatic liver tumors) were treated with SBRT. Results: The median follow-up was 9 months (range=1-76) for all patients. Local control was reached in 27 out of 34 (79%) treated lesions, with 1 and 2 years rates of 93% and 73%, respectively. The progression-free survival at 1-year and 2-year was 50% and 25%, respectively. Median overall survival was 16 months (95% confidence interval=8-24 months), with 1-year and 2-year rates of 58% and 41%, respectively. Toxicity was very low consisting mainly of grade 1 and 2 events. Conclusion: SBRT provides good local control for both primary and metastatic liver lesions, with minimal toxicity.
2015
Caivano, D., Bracci, S., Russo, I., Montalto, A., Armosini, V., De Sanctis, V., et al. (2015). Stereotactic body radiation therapy for liver lesions. A single-institution experience. ANTICANCER RESEARCH, 35(7), 4171-4176.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/1126508
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