The differentiation between radiation-induced changes and tumor recurrence is a major pitfall of magnetic resonance imaging, which can be overcome by the use of PET. Although amino-acid PET tracers showed several advantages over 18F-fluorodeoxyglucose in neurooncology, studies comparing these 2 types of radiopharmaceuticals in previously irradiated brain metastases are lacking. Here, we demonstrated a mismatch between 3,4-dihydroxy-6-[18F]-fluoro-l-phenylalanine (F-DOPA) and FDG in the first report of a previously irradiated brain metastasis undergoing a longitudinal evaluation by sequential double tracer PET imaging.
Cicone, F., Carideo, L., Villani, V., Scaringi, C., Bozzao, A., Scopinaro, F., et al. (2020). Metabolic Evolution of Brain Metastasis after Stereotactic Radiosurgery: Mismatch between F-DOPA and FDG PET. CLINICAL NUCLEAR MEDICINE, 45(7), 557-558 [10.1097/RLU.0000000000003070].
Metabolic Evolution of Brain Metastasis after Stereotactic Radiosurgery: Mismatch between F-DOPA and FDG PET
Minniti G.
2020-01-01
Abstract
The differentiation between radiation-induced changes and tumor recurrence is a major pitfall of magnetic resonance imaging, which can be overcome by the use of PET. Although amino-acid PET tracers showed several advantages over 18F-fluorodeoxyglucose in neurooncology, studies comparing these 2 types of radiopharmaceuticals in previously irradiated brain metastases are lacking. Here, we demonstrated a mismatch between 3,4-dihydroxy-6-[18F]-fluoro-l-phenylalanine (F-DOPA) and FDG in the first report of a previously irradiated brain metastasis undergoing a longitudinal evaluation by sequential double tracer PET imaging.
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https://hdl.handle.net/11365/1126356
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