Background: The optimal management of hand osteoarthritis (HOA) is still challenging. Aim: To evaluate the effects of glucosamine sulfate (GS) in addition to conventional therapy compared to conventional therapy alone in HOA. Methods: This 6-month retrospective study included 108 patients with concomitant knee and hand OA. Fifty-five patients (GS Group) were treated for six consecutive months with crystalline GS (1500 mg once/day) in addition to conventional therapy for HOA [exercise combined with acetaminophen and/or non-steroidal anti-inflammatory drugs (NSAIDs)] and 53 patients (Control Group) with the conventional therapy alone. Primary outcomes were the difference between groups in the change of hand pain on a Visual Analogue Scale (VAS) and in the Functional Index for Hand Osteoarthritis (FIHOA) from baseline to 6 months. Secondary outcomes were Health Assessment Questionnaire (HAQ), medical outcomes study 36-item short form (SF-36) and symptomatic drug consumption. Results: The patients who received GS presented a significant decrease (p < 0.001) in VAS pain and FIHOA scores compared with the Control Group at 3 and 6 months. Furthermore, GS therapy was associated to a significant improvement of HAQ score and to a significant reduction of acetaminophen and NSAID consumption during the follow-up. No differences in the number of side effects were observed between the groups. Discussion: GS could represent a potential successful therapy for HOA and should be tried in large randomized placebo and active controlled trials. Conclusions: The combination of GS with conventional treatment seems to be more effective in improving pain and function than conventional HOA treatment alone. Trial registration: ClinicalTrials.gov, http://www.clinicaltrials.gov date of registration: April 9, 2019, NCT03911570. The present trial was retrospectively registered. © 2019, Springer Nature Switzerland AG.

Tenti, S., Giordano, N., Mondanelli, N., Giannotti, S., Maheu, E., Fioravanti, A. (2020). A retrospective observational study of glucosamine sulfate in addition to conventional therapy in hand osteoarthritis patients compared to conventional treatment. AGING CLINICAL AND EXPERIMENTAL RESEARCH, 32(6), 1161-1172 [10.1007/s40520-019-01305-4].

A retrospective observational study of glucosamine sulfate in addition to conventional therapy in hand osteoarthritis patients compared to conventional treatment

Tenti S.;Giordano N.;Mondanelli N.;Giannotti S.;Fioravanti A.
2020-01-01

Abstract

Background: The optimal management of hand osteoarthritis (HOA) is still challenging. Aim: To evaluate the effects of glucosamine sulfate (GS) in addition to conventional therapy compared to conventional therapy alone in HOA. Methods: This 6-month retrospective study included 108 patients with concomitant knee and hand OA. Fifty-five patients (GS Group) were treated for six consecutive months with crystalline GS (1500 mg once/day) in addition to conventional therapy for HOA [exercise combined with acetaminophen and/or non-steroidal anti-inflammatory drugs (NSAIDs)] and 53 patients (Control Group) with the conventional therapy alone. Primary outcomes were the difference between groups in the change of hand pain on a Visual Analogue Scale (VAS) and in the Functional Index for Hand Osteoarthritis (FIHOA) from baseline to 6 months. Secondary outcomes were Health Assessment Questionnaire (HAQ), medical outcomes study 36-item short form (SF-36) and symptomatic drug consumption. Results: The patients who received GS presented a significant decrease (p < 0.001) in VAS pain and FIHOA scores compared with the Control Group at 3 and 6 months. Furthermore, GS therapy was associated to a significant improvement of HAQ score and to a significant reduction of acetaminophen and NSAID consumption during the follow-up. No differences in the number of side effects were observed between the groups. Discussion: GS could represent a potential successful therapy for HOA and should be tried in large randomized placebo and active controlled trials. Conclusions: The combination of GS with conventional treatment seems to be more effective in improving pain and function than conventional HOA treatment alone. Trial registration: ClinicalTrials.gov, http://www.clinicaltrials.gov date of registration: April 9, 2019, NCT03911570. The present trial was retrospectively registered. © 2019, Springer Nature Switzerland AG.
2020
Tenti, S., Giordano, N., Mondanelli, N., Giannotti, S., Maheu, E., Fioravanti, A. (2020). A retrospective observational study of glucosamine sulfate in addition to conventional therapy in hand osteoarthritis patients compared to conventional treatment. AGING CLINICAL AND EXPERIMENTAL RESEARCH, 32(6), 1161-1172 [10.1007/s40520-019-01305-4].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/1124164