Introduction: This case report presents two patients affected by a very rare association of bilateral retinoblastoma and osteogenesis imperfecta. Case report: Two Caucasian males with familial history and clinical signs of osteogenesis imperfecta came to our attention for bilateral leukocoria. The ocular fundus examination revealed bilateral retinoblastoma. Proper therapies were dispensed in order to achieve full regression. Genetic counseling was performed. Discussion: The primary role of genetics in retinoblastoma pathogenesis in widely known, and different genes have been identified. Osteogenesis imperfecta is a rare connective tissue disorders, caused by mutated genes encoding for collagen. The single gene defect in osteogenesis imperfecta type VI is Serpin Family F Member 1 (SERPINF1), a neurotrophic factor for the neuronal differentiation in retinoblastoma cells. The association of bilateral retinoblastoma and osteogenesis imperfecta could be the result of the mutation of a single gene playing a role in a hypothetical common pathway. © The Author(s) 2020.

De Francesco, S., Sgheri, A., Di Maggio, A., Rana, F., Pinto, A.M., Renieri, A., et al. (2021). Bilateral retinoblastoma and osteogenesis imperfecta, a very rare association: Two cases. EUROPEAN JOURNAL OF OPHTHALMOLOGY, 31(3), NP81-NP84 [10.1177/1120672120919344].

Bilateral retinoblastoma and osteogenesis imperfecta, a very rare association: Two cases

De Francesco S.;Sgheri A.;Di Maggio A.;Rana F.;Pinto A. M.;Renieri A.;Hadjistilianou T.
2021-01-01

Abstract

Introduction: This case report presents two patients affected by a very rare association of bilateral retinoblastoma and osteogenesis imperfecta. Case report: Two Caucasian males with familial history and clinical signs of osteogenesis imperfecta came to our attention for bilateral leukocoria. The ocular fundus examination revealed bilateral retinoblastoma. Proper therapies were dispensed in order to achieve full regression. Genetic counseling was performed. Discussion: The primary role of genetics in retinoblastoma pathogenesis in widely known, and different genes have been identified. Osteogenesis imperfecta is a rare connective tissue disorders, caused by mutated genes encoding for collagen. The single gene defect in osteogenesis imperfecta type VI is Serpin Family F Member 1 (SERPINF1), a neurotrophic factor for the neuronal differentiation in retinoblastoma cells. The association of bilateral retinoblastoma and osteogenesis imperfecta could be the result of the mutation of a single gene playing a role in a hypothetical common pathway. © The Author(s) 2020.
De Francesco, S., Sgheri, A., Di Maggio, A., Rana, F., Pinto, A.M., Renieri, A., et al. (2021). Bilateral retinoblastoma and osteogenesis imperfecta, a very rare association: Two cases. EUROPEAN JOURNAL OF OPHTHALMOLOGY, 31(3), NP81-NP84 [10.1177/1120672120919344].
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/1121745