We have analysed the sequence organization of the pseudoautosomal region at the telomeres of the long arms of the human sex chromosomes and shown that it is 320 kb long. A LINE sequence is present on both the X and Y chromosomes immediately adjacent to the breakpoint in homology suggesting that the homology arose as a result of an ectopic recombination event mediated by LINE sequences originally present in non-homologous stretches of X and Y chromosomal DNA. This led to the translocation of sequences from the X chromosome telomere onto the Y chromosome and created a new pseudoautosomal region.
|Titolo:||The sequence organization of the long arm pseudoautosomal region of the human sex chromosomes.|
|Citazione:||K., K., Galvagni, F., & W., B. (1994). The sequence organization of the long arm pseudoautosomal region of the human sex chromosomes. HUMAN MOLECULAR GENETICS, 3, 771-778.|
|Appare nelle tipologie:||1.1 Articolo in rivista|
File in questo prodotto: