Abstract:  In this study, we evaluated the efficacy of fludarabine (FLU), an adenine nucleoside analogue, in 35 previously treated patients with advanced and progressed B‐cell chronic lymphocytic leukemia (B‐CLL) and in 6 at diagnosis. All patients were treated at a dose of 25 mg/m2 per day for 5 consecutive days (mean number of courses was 5, with a range from 4 to 6). The majority of patients experienced a beneficial effect on hematological parameters. In particular, a remarkable reduction of lymphocyte count together with an increase of neutrophils and platelets was observed. The overall response rate was 42% with 1 complete response and 16 partial responses. Ten patients achieved minor responses and the remaining 14 showed no benefit from treatment. An increased response rate was achieved in 6 untreated patients who showed an overall response rate of 67% (4/6). The major complications observed were neutropenia (66%) and febrile episodes (44%) that were generally infection‐related and were fatal in 3 cases. Because we were dealing with patients whose disease was advanced and/or resistant to treatment, the overall results may be considered encouraging with acceptable toxic reactions not superior to those frequently observed with polychemotherapy. © Munksgaard 1993

Zinzani, P.L., Lauria, F., Rondelli, D., Benfenati, D., Raspadori, D., Bocchia, M., et al. (1993). Fludarabine in patients with advanced and/or resistant B‐chronic lymphocytic leukemia. EUROPEAN JOURNAL OF HAEMATOLOGY, 51(2), 93-97 [10.1111/j.1600-0609.1993.tb01599.x].

Fludarabine in patients with advanced and/or resistant B‐chronic lymphocytic leukemia

Raspadori D.;Bocchia M.;Gozzetti A.;Fiacchini M.;
1993-01-01

Abstract

Abstract:  In this study, we evaluated the efficacy of fludarabine (FLU), an adenine nucleoside analogue, in 35 previously treated patients with advanced and progressed B‐cell chronic lymphocytic leukemia (B‐CLL) and in 6 at diagnosis. All patients were treated at a dose of 25 mg/m2 per day for 5 consecutive days (mean number of courses was 5, with a range from 4 to 6). The majority of patients experienced a beneficial effect on hematological parameters. In particular, a remarkable reduction of lymphocyte count together with an increase of neutrophils and platelets was observed. The overall response rate was 42% with 1 complete response and 16 partial responses. Ten patients achieved minor responses and the remaining 14 showed no benefit from treatment. An increased response rate was achieved in 6 untreated patients who showed an overall response rate of 67% (4/6). The major complications observed were neutropenia (66%) and febrile episodes (44%) that were generally infection‐related and were fatal in 3 cases. Because we were dealing with patients whose disease was advanced and/or resistant to treatment, the overall results may be considered encouraging with acceptable toxic reactions not superior to those frequently observed with polychemotherapy. © Munksgaard 1993
Zinzani, P.L., Lauria, F., Rondelli, D., Benfenati, D., Raspadori, D., Bocchia, M., et al. (1993). Fludarabine in patients with advanced and/or resistant B‐chronic lymphocytic leukemia. EUROPEAN JOURNAL OF HAEMATOLOGY, 51(2), 93-97 [10.1111/j.1600-0609.1993.tb01599.x].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/1116215
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